Otorhinolaryngology Department, Faculty of Medicine, Menoufia University, Shibin el Kom, Egypt.
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Shibin el Kom, Egypt.
Am J Rhinol Allergy. 2021 Sep;35(5):640-646. doi: 10.1177/1945892420983787. Epub 2020 Dec 23.
Different biomarkers are detectable in cases of chronic rhinosinusitis with nasal polyposis (CRSwNP) with need for evaluation of their diagnostic and prognostic roles.
To assess the serum levels of total IgE, interleukin-17 and Pentraxin-3 in patients with CRSwNP and correlate them with the clinical evaluation using Sino-Nasal Outcome Test (SNOT-22), radiological evaluation using Lund - Mackay (LM) computed tomography scan score, and polyposis recurrence.
This cross-sectional comparative study was carried out on fifty patients with CRSwNP and twenty-five age and gender matched healthy volunteers as control group. Patients were assessed clinically by SNOT-22 and radiologically by LM score. Blood samples of patients and controls were analyzed for serum levels of total immunoglobulin E (IgE), Interleukin-17 (IL-17) and Pentraxin-3 (PTX-3). The correlation between the serum levels of every two markers of the study markers was assessed. The levels of the three biomarkers were correlated with SNOT-22 and LM scores and polyp recurrence with assessment of their sensitivity and specificity to diagnose CRSwNP.
This study showed significantly higher values of the three biomarkers in patients group compared with control group (p < 0.001 for all). There were significant positive correlations between the levels of the three markers and SNOT 22 and LM scores (p < 0.001 for all) and with recurrence of polyposis (p < 0.001, p = 0.005 and p = 0.032 respectively). Agreement (sensitivity and specificity) for these markers to diagnose patient group was statistically significant (p < 0.001 for all). There was a significant positive correlation between every two markers of the study markers.
Serum levels of total IgE, IL-17 and PTX-3 are important biological markers for diagnosis and follow up of cases of CRSwNP with high sensitivity and specificity in detection of such cases. They should be included in the routine laboratory workup for cases of CRSwNP.
在慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）患者中，有多种生物标志物可被检测到，需要评估它们在诊断和预后方面的作用。
评估 CRSwNP 患者血清总 IgE、白细胞介素-17 和 Pentraxin-3 的水平，并与 Sino-Nasal Outcome Test（SNOT-22）临床评估、Lund-Mackay（LM）计算机断层扫描评分的放射学评估以及息肉复发进行相关性分析。
本研究为横断面对照研究，纳入 50 例 CRSwNP 患者和 25 名年龄和性别相匹配的健康志愿者作为对照组。患者进行 SNOT-22 临床评估和 LM 评分放射学评估。检测患者和对照组血清总免疫球蛋白 E（IgE）、白细胞介素-17（IL-17）和 Pentraxin-3（PTX-3）水平。评估研究标志物中每两个标志物之间的血清水平相关性。评估三种生物标志物与 SNOT-22 和 LM 评分以及息肉复发之间的相关性，并评估其诊断 CRSwNP 的敏感性和特异性。
与对照组相比，患者组的三种标志物水平显著升高（均 p<0.001）。三种标志物的水平与 SNOT 22 和 LM 评分呈显著正相关（均 p<0.001），与息肉复发呈显著正相关（均 p<0.001、p=0.005 和 p=0.032）。这些标志物诊断患者组的一致性（敏感性和特异性）具有统计学意义（均 p<0.001）。研究标志物的每两个标志物之间存在显著正相关。
血清总 IgE、IL-17 和 PTX-3 水平是 CRSwNP 诊断和随访的重要生物学标志物，具有较高的敏感性和特异性，可用于 CRSwNP 的常规实验室检查。
