[Clinical and experimental experiences with maprotiline, clomipramine, sydnocarb and mefexamide in mentally-ill patients and in healthy persons].

In the present paper we studied the clinical effects of psychotropic drugs. In the experimental part we studied their effects on our patients and normal subjects and compared it with the results obtained with the placebo treatment. We studied the effect on attention (A), efficiency (E) psychomotor rate (PR), numerical quadrate, Bourdon test, tapping and some functions of the vegetative nervous system, the mean orthostatic acceleration (MOA), the clinostatic retardation (CR), the tonus of the sympathetic (TS) and of the vagus (TV). Sydnocarb is an effective psychostimulating agent. The is no evident influence on VN in doses between 5 and 15 mg (23 patients). It accelerated psychomotor rate (24 patients). E, A, PR are only slightly increased by Mephexamid (40 patients). Maprotiline (20) patients caused an increase in E, PR and slightly in A. Under the influence of Sydnocarb, Mephexamid and Maprotiline the value of MOA, CR, TS, TV remained unchanged. Clomipramin was administered in 20 patients in the experimental part and in 40 patients in the clinical part of our study. In the course of the clinical trial we discovered that Clomipramine decreased the irritability of the vegetative nervous system and through this effect causes deserved general sedation of the organism.