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具有时变协变量的反馈的两阶段广义矩方法模型。

A two-stage Generalized Method of Moments model for feedback with time-dependent covariates.

机构信息

School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ, USA.

出版信息

Stat Methods Med Res. 2021 Apr;30(4):943-957. doi: 10.1177/0962280220981402. Epub 2020 Dec 27.

Abstract

Correlated observations in longitudinal studies are often due to repeated measures on the subjects. Additionally, correlation may be realized due to the association between responses at a particular time and the predictors at earlier times. There are also feedback effects (relation between responses in the present and the covariates at a later time), though these are not always relevant and are often ignored. All these cases of correlation must be accounted for as they can have different effects on the regression coefficients. Several authors have provided models that reflect the direct and delayed impact of covariates on the response, utilizing valid moment conditions to estimate the relevant regression coefficients. However, there are applications when one cannot ignore the effect of the responses on future covariates. A two-stage model to account for the feedback, modeling the direct as well as the delayed effects of the covariates on future responses and vice versa is presented. The use of the two-stage model is demonstrated by revisiting child morbidity and its impact on future values of body mass index using Philippines health data. Also, obesity status and its feedback effects on physical activity and depression levels using the Add Health dataset are analyzed.

摘要

纵向研究中的相关观测通常是由于对研究对象进行了重复测量。此外,相关性也可能是由于特定时间的反应与较早时间的预测因子之间的关联所致。还存在反馈效应(当前反应与以后协变量之间的关系),尽管这些效应并不总是相关的,并且通常被忽略。所有这些相关情况都必须加以考虑,因为它们可能对回归系数产生不同的影响。一些作者已经提供了模型,这些模型反映了协变量对反应的直接和延迟影响,利用有效的矩条件来估计相关的回归系数。但是,在某些情况下,不能忽略反应对未来协变量的影响。本文提出了一种两阶段模型,以考虑反馈,对协变量对未来反应的直接和延迟影响进行建模,反之亦然。通过使用菲律宾健康数据重新研究儿童发病率及其对未来体重指数值的影响,展示了两阶段模型的使用。还使用 Add Health 数据集分析了肥胖状况及其对身体活动和抑郁水平的反馈效应。

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