School of Pharmacy, Sungkyunkwan University, Suwon Republic of Korea.
J Toxicol Environ Health B Crit Rev. 2021 Apr 3;24(3):95-118. doi: 10.1080/10937404.2020.1860842. Epub 2020 Dec 23.
Curcumin, used as a spice and traditional medicine in India, exerts beneficial effects against several diseases, owing to its antioxidant, analgesic, and anti-inflammatory properties. Evidence indicates that curcumin might protect against heavy metal-induced organ toxicity by targeting biological pathways involved in anti-oxidation, anti-inflammation, and anti-tumorigenesis. Curcumin has received considerable attention owing to its therapeutic properties, and the mechanisms underlying some of its actions have been recently investigated. Cadmium (Cd) is a heavy metal found in the environment and used extensively in industries. Chronic Cd exposure induces damage to bones, liver, kidneys, lungs, testes, and the immune and cardiovascular systems. Because of its long half-life, exposure to even low Cd levels might be harmful. Cd-induced toxicity involves the overproduction of reactive oxygen species (ROS), resulting in oxidative stress and damage to essential biomolecules. Dietary antioxidants, such as chelating agents, display the potential to reduce Cd accumulation and metal-induced toxicity. Curcumin scavenges ROS and inhibits oxidative damage, thus resulting in many therapeutic properties. This review aims to address the effectiveness of curcumin against Cd-induced organ toxicity and presents evidence supporting the use of curcumin as a protective antioxidant.
姜黄，在印度用作香料和传统药物，具有抗氧化、镇痛和抗炎特性，因此对多种疾病具有有益的作用。有证据表明，姜黄可能通过针对抗氧化、抗炎和抗肿瘤发生的生物途径来预防重金属引起的器官毒性。由于其治疗特性，姜黄受到了相当多的关注，其一些作用的机制最近也得到了研究。镉（Cd）是一种存在于环境中并广泛用于工业的重金属。慢性镉暴露会导致骨骼、肝脏、肾脏、肺部、睾丸以及免疫系统和心血管系统受损。由于其半衰期长，即使接触低水平的 Cd 也可能有害。镉诱导的毒性涉及活性氧（ROS）的过度产生，导致氧化应激和对重要生物分子的损伤。膳食抗氧化剂，如螯合剂，具有减少 Cd 积累和金属诱导毒性的潜力。姜黄清除 ROS 并抑制氧化损伤，从而具有许多治疗特性。本综述旨在探讨姜黄对 Cd 诱导的器官毒性的有效性，并提供支持使用姜黄作为保护性抗氧化剂的证据。
