Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, People's Republic of China.
Hematology. 2021 Dec;26(1):9-15. doi: 10.1080/16078454.2020.1860359.
Ras-related dexamethasone-induced 1 () is abnormally expressed in many solid cancers. However, its potential role in adults with B-cell acute lymphoblastic leukemia (B-ALL) is unclear. Therefore, we aim to clarify the abnormal expression of the tumor-associated biomarker, , as a potential target for diagnosis and prognosis in adult Philadelphia-negative B-ALL.
The expression of was detected with RT-qPCR in 92 adults with de novo Ph-negative B-ALL and 40 healthy controls. The correlation between transcript levels and relapse was assessed.
transcript levels in patients with Ph-negative B-ALL (median 81.76%, range 0.22%-1824.52%) were significantly higher than those in healthy controls (7.59%, 0.46%-38.66%; <0.0001). Patients with low transcript levels had a lower 5-year relapse-free survival (RFS, 47.5% [32.9%, 62.1%] vs. 63.1% [49.0%, 77.2%]; = 0.012) and a higher 5-year cumulative incidence of relapse (CIR, 52.0% [37.4%, 66.6%] vs. 36.2% [22.2%, 50.2%]; = 0.013) especially in patients receiving chemotherapy only. Multivariate analysis showed that a low transcript level was an independent risk factor for RFS (HR = 2.938 [1.427, 6.047], = 0.003) and CIR (HR = 3.367 [1.668, 6.796], = 0.001) in patients with Ph-negative B-ALL.
transcript levels were significantly higher in patients with Ph-negative B-ALL and a low transcript level was independently correlated with increased relapse risk.
Ras 相关的地塞米松诱导蛋白 1 () 在许多实体瘤中异常表达。然而，其在成人 B 细胞急性淋巴细胞白血病（B-ALL）中的潜在作用尚不清楚。因此，我们旨在阐明肿瘤相关生物标志物的异常表达，即作为成人费城染色体阴性 B-ALL 诊断和预后的潜在靶点。
采用 RT-qPCR 检测 92 例初诊 Ph 阴性 B-ALL 成人患者和 40 例健康对照者中 的表达。评估 转录水平与复发的相关性。
Ph 阴性 B-ALL 患者的 转录水平（中位数 81.76%，范围 0.22%-1824.52%）明显高于健康对照组（7.59%，0.46%-38.66%；<0.0001）。低 转录水平的患者 5 年无复发生存率（RFS，47.5%[32.9%，62.1%]比 63.1%[49.0%，77.2%]；=0.012）和 5 年累积复发率（CIR，52.0%[37.4%，66.6%]比 36.2%[22.2%，50.2%]；=0.013）均较低，尤其是仅接受化疗的患者。多因素分析显示，低 转录水平是 Ph 阴性 B-ALL 患者 RFS（HR=2.938[1.427，6.047]，=0.003）和 CIR（HR=3.367[1.668，6.796]，=0.001）的独立危险因素。
Ph 阴性 B-ALL 患者 的转录水平明显升高，低 转录水平与复发风险增加独立相关。
