Department of Pathology, Wrocław Medical University, Wrocław, Poland.
Department of Maxillofacial Orthopaedics and Orthodontics, Wrocław Medical University, Wrocław, Poland.
J Histotechnol. 2021 Mar;44(1):46-51. doi: 10.1080/01478885.2020.1861918. Epub 2020 Dec 24.
Syndecan-1 (SDC1) belongs to heparan sulfate proteoglycans which may interact with different growth factors, cytokines, morphogens and promote tumor growth and invasion. The aim of the present study was to assess the immunohistochemical expression of syndecan-1 in oral squamous cell carcinoma (OSCC) and oral cysts. Evaluation of the staining pattern with the clinico-histological characteristics of patients was performed. A total of 42 OSCC and 23 oral cysts tissue samples were examined. Statistical tests were used for the significance analysis. The positive expression of syndecan-1 was significantly higher in OSCC compared to cyst located in the oral cavity. Moreover, the results indicate that the intensity of the expression correlated with grading score (p = 0.046). The data indicate that syndecan-1 is altered in OSCC and its excessive amount relates in a predictive manner to neoplastic transformation. As such, SDC1 expression may be used as an adjunctive biomarker in molecular diagnostics of oral squamous cell carcinoma.
硫酸乙酰肝素蛋白聚糖-1（SDC1）属于硫酸乙酰肝素蛋白聚糖家族，可与不同的生长因子、细胞因子、形态发生素相互作用，促进肿瘤生长和侵袭。本研究旨在评估硫酸乙酰肝素蛋白聚糖-1在口腔鳞状细胞癌（OSCC）和口腔囊肿中的免疫组织化学表达。评估了与患者临床病理特征相关的染色模式。共检测了 42 例 OSCC 和 23 例口腔囊肿组织样本。采用统计学方法进行显著性分析。与口腔囊肿相比，OSCC 中硫酸乙酰肝素蛋白聚糖-1的阳性表达显著升高。此外，结果表明，表达强度与分级评分相关（p=0.046）。数据表明，硫酸乙酰肝素蛋白聚糖-1在 OSCC 中发生改变，其过量表达与肿瘤转化呈预测性相关。因此，SDC1 表达可作为口腔鳞状细胞癌分子诊断的辅助生物标志物。
