Iwasaki K, Gleiser C A, Masoro E J, McMahan C A, Seo E J, Yu B P
Department of Physiology, University of Texas Health Science Center at San Antonio.
J Gerontol. 1988 Jan;43(1):B5-12. doi: 10.1093/geronj/43.1.b5.
The influence of replacing dietary casein with soy protein on longevity and age-related pathologic lesions of male Fischer 344 rats was investigated. Caloric intake and body weights were similar for rats on the two diets. Rats on the soy protein-containing diet had a median length of life of 844 days compared to 730 days for those on the casein-containing diet (p less than .002), and the ages of the 10th percentile survivors were 937 and 857 days, respectively (p less than .02). The progression of chronic nephropathy was markedly retarded by replacing casein with soy protein. Only 7% of the rats dying spontaneously on the soy protein-containing diet exhibited end-stage chronic nephropathy compared to 41% of the rats on the casein-containing diet. Clearly, the soy protein-containing diet enables ad libitum fed male Fischer 344 rats to be used as a model for aging research without the occurrence of renal failure as a major confounding problem.
研究了用大豆蛋白替代膳食酪蛋白对雄性Fischer 344大鼠寿命和与年龄相关的病理损伤的影响。两种饮食的大鼠热量摄入和体重相似。含大豆蛋白饮食的大鼠中位寿命为844天，而含酪蛋白饮食的大鼠为730天（p<0.002），第10百分位数存活者的年龄分别为937天和857天（p<0.02）。用大豆蛋白替代酪蛋白可显著延缓慢性肾病的进展。在含大豆蛋白饮食中自然死亡的大鼠中，只有7%表现出终末期慢性肾病，而含酪蛋白饮食的大鼠中这一比例为41%。显然，含大豆蛋白的饮食使随意进食的雄性Fischer 344大鼠能够用作衰老研究的模型，而不会出现肾衰竭这一主要混杂问题。
