Jaslok Hospital and Research Centre, Cardiology Reception, 17th Floor, 15, Pedder Road, Mumbai, 400026, India.
Jaslok Hospital and Research Centre, Cardiology Reception, 17th Floor, 15, Pedder Road, Mumbai, 400026, India.
Indian Heart J. 2020 Nov-Dec;72(6):603-605. doi: 10.1016/j.ihj.2020.10.004. Epub 2020 Oct 20.
We investigated the diagnostic utility and safety of intracoronary bolus administration of nicorandil compared with intravenous administration of adenosine for evaluating FFR in patients with intermediate (40-70%) coronary stenosis. The FFR values obtained with nicorandil and adenosine showed linear relationship. This correlation is statistically significant with regression coefficient of 0.932 (R2 = 0.834, p < 0.001). The side effects such as bronchospasm, hypotension, and bradycardia were significantly higher after administration of adenosine compared to nicorandil (20% vs. 1.66%, p = 0.001). Intracoronary use of nicorandil seems to be promising in offering the advantages of lesser side effects, similar efficacy, and lesser cost as compared to adenosine.
我们研究了与静脉内给予腺苷相比，冠状动脉内推注硝酸异山梨酯评估中度（40%-70%）冠状动脉狭窄患者的血流储备分数（FFR）的诊断效能和安全性。硝酸异山梨酯和腺苷获得的 FFR 值呈线性关系。这种相关性具有统计学意义，回归系数为 0.932（R2=0.834，p<0.001）。与硝酸异山梨酯相比，静脉内给予腺苷后，支气管痉挛、低血压和心动过缓等副作用明显更高（20%比 1.66%，p=0.001）。与腺苷相比，冠状动脉内使用硝酸异山梨酯似乎具有副作用更小、疗效相似、成本更低的优势。
