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Efficacy of sonidegib in histologic subtypes of advanced basal cell carcinoma: Results from the final analysis of the randomized phase 2 Basal Cell Carcinoma Outcomes With LDE225 Treatment (BOLT) trial at 42 months.

作者信息

Dummer Reinhard, Lear John T, Guminski Alex, Leow Liang Joo, Squittieri Nicholas, Migden Michael

机构信息

Department of Dermatology, University Hospital Zürich, University of Zürich, Zürich, Switzerland.

Department of Dermatology, Salford Royal National Health Service Foundation Trust, Salford, United Kingdom.

出版信息

J Am Acad Dermatol. 2021 Apr;84(4):1162-1164. doi: 10.1016/j.jaad.2020.08.042. Epub 2020 Dec 24.

DOI:10.1016/j.jaad.2020.08.042
PMID:33358380
Abstract
摘要

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Efficacy of sonidegib in histologic subtypes of advanced basal cell carcinoma: Results from the final analysis of the randomized phase 2 Basal Cell Carcinoma Outcomes With LDE225 Treatment (BOLT) trial at 42 months.索尼德吉治疗晚期基底细胞癌组织学亚型的疗效：LDE225治疗基底细胞癌结局（BOLT）随机2期试验42个月最终分析结果
J Am Acad Dermatol. 2021 Apr;84(4):1162-1164. doi: 10.1016/j.jaad.2020.08.042. Epub 2020 Dec 24.
2
The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): A phase II, randomized, double-blind study of sonidegib in patients with advanced basal cell carcinoma.BOLT 研究：隆地替尼治疗基底细胞癌的 12 个月分析：一项评价晚期基底细胞癌患者接受 sonidegib 治疗的 II 期、随机、双盲研究。
J Am Acad Dermatol. 2016 Jul;75(1):113-125.e5. doi: 10.1016/j.jaad.2016.02.1226. Epub 2016 Apr 7.
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Sonidegib for the treatment of advanced basal cell carcinoma: a comprehensive review of sonidegib and the BOLT trial with 12-month update.索尼替尼治疗晚期基底细胞癌：全面综述索尼替尼和 BOLT 试验及其 12 个月更新。
Future Oncol. 2016 Sep;12(18):2095-105. doi: 10.2217/fon-2016-0118. Epub 2016 May 18.
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Treatment of advanced basal cell carcinoma with sonidegib: perspective from the 30-month update of the BOLT trial.索立德吉治疗晚期基底细胞癌：BOLT 试验 30 个月更新的观点。
Future Oncol. 2018 Mar;14(6):515-525. doi: 10.2217/fon-2017-0457. Epub 2017 Nov 9.
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Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study.索立德吉治疗局部晚期和转移性基底细胞癌患者的长期疗效和安全性：随机 2 期 BOLT 研究的 30 个月分析。
J Eur Acad Dermatol Venereol. 2018 Mar;32(3):372-381. doi: 10.1111/jdv.14542. Epub 2017 Nov 6.
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Response to "Efficacy of sonidegib in histologic subtypes of advanced basal cell carcinoma: Results from the final analysis of the randomized phase 2 Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT) trial at 42 months".
J Am Acad Dermatol. 2021 Jun;84(6):e299-e300. doi: 10.1016/j.jaad.2021.02.074. Epub 2021 Mar 4.
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Sonidegib (Odomzo°) and extensive basal cell carcinoma.索尼德吉（奥多姆佐°）与广泛性基底细胞癌。
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Long-term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase II randomized, double-blind BOLT study.索立德吉治疗晚期基底细胞癌的长期疗效和安全性：II 期随机、双盲 BOLT 研究的 42 个月分析。
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Dermatoscopy and locally advanced or multiple basal cell carcinomas: a non-invasive tool to evaluate sonidegib effectiveness.皮肤镜与局部晚期或多发性基底细胞癌：一种评估索尼德吉疗效的非侵入性工具。
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J Clin Aesthet Dermatol. 2025 Mar;18(3):21-27.
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Cancers (Basel). 2024 Dec 29;17(1):68. doi: 10.3390/cancers17010068.
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J Dtsch Dermatol Ges. 2024 Dec;22(12):1697-1714. doi: 10.1111/ddg.15566. Epub 2024 Nov 25.
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Clinical Clearance Following Improvement of Histologic Subtype of Basal Cell Carcinoma with Sonidegib.使用索尼德吉治疗后基底细胞癌组织学亚型改善后的临床清除情况
Acta Derm Venereol. 2022 Nov 7;102:adv00809. doi: 10.2340/actadv.v102.2740.
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Experience with sonidegib in patients with advanced basal cell carcinoma: case reports.晚期基底细胞癌患者使用索尼德吉的经验：病例报告
Drugs Context. 2022 May 23;11. doi: 10.7573/dic.2022-3-8. eCollection 2022.
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Biomedicines. 2021 Sep 10;9(9):1188. doi: 10.3390/biomedicines9091188.