Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.
Pathology. 2021 Feb;53(2):166-169. doi: 10.1016/j.pathol.2020.10.008. Epub 2020 Dec 25.
Mixed germ cell-sex cord stromal tumours (MGC-SCSTs) of the testis and ovary differ significantly in their histological appearance, clinical behaviour, and molecular genetics. Until recently, the germ cells of testicular MGC-SCST were considered to be invariably histologically bland, whereas those from neoplasms that arise in the ovary have histological features characteristic of premalignancy. However, a recent histological and molecular genetic study demonstrated histological abnormalities and multiple chromosomal losses and gains in a small subset of testicular cases, thus providing the first evidence that testicular MGC-SCSTs can exceptionally show histological and molecular abnormalities. All cases of testicular MGC-SCST reported to date have been clinically benign, whereas ovarian examples are sometimes the precursor of a malignant germ cell neoplasm that can be clinically aggressive. Both genetic and epigenetic influences likely account for dissimilarities in these uncommon gonadal neoplasms.
睾丸和卵巢的混合性生殖细胞-性索间质肿瘤（MGC-SCST）在组织学表现、临床行为和分子遗传学上有显著差异。直到最近，人们一直认为睾丸 MGC-SCST 的生殖细胞在组织学上始终是温和的，而那些来源于卵巢的肿瘤具有癌前病变的特征。然而，最近的一项组织学和分子遗传学研究表明，一小部分睾丸病例存在组织学异常和多种染色体缺失和获得，这首次提供了证据表明睾丸 MGC-SCST 可能异常表现出组织学和分子异常。迄今为止报道的所有睾丸 MGC-SCST 病例均为临床良性，而卵巢病例有时是恶性生殖细胞瘤的前体，后者可能具有侵袭性的临床特征。遗传和表观遗传的影响可能解释了这些罕见性腺肿瘤的不同。
