白癜风与听力损失之间的关联。
Association between vitiligo and hearing loss.
作者信息
Ma Sheng-Hsiang, Ang Min-De, Chang Yun-Ting, Dai Ying-Xiu
机构信息
Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
School of Medicine, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.
出版信息
J Am Acad Dermatol. 2021 Dec;85(6):1465-1472. doi: 10.1016/j.jaad.2020.12.029. Epub 2021 Jan 22.
BACKGROUND
Vitiligo is a common depigmenting disorder caused by the autoimmune destruction of melanocytes. Some evidence suggests the involvement of melanocytes in the auditory system in the disease process. However, the relationship between vitiligo and sensorineural hearing loss (SNHL) remains uncertain.
OBJECTIVE
We investigated the association between vitiligo and SNHL.
METHODS
In this systematic review and meta-analysis, EMBASE, MEDLINE, PubMed, and the Cochrane database were searched for studies examining the association between SNHL and vitiligo from inception to June 28, 2020.
RESULTS
A total of 14 case-control studies with 938 patients with vitiligo were included. The meta-analysis showed a significant association of SNHL with vitiligo (odds ratio [OR] 6.02 [95% confidence interval {CI} 3.41-10.62]). The association remained significant after adjustment of study quality and publication bias, with ORs of 5.30 (95% CI 1.53-18.35), and 3.45 (95% CI 1.75-6.81), respectively.
LIMITATIONS
Heterogenous definition and measurement of hearing loss and racial differences are potential sources of bias.
CONCLUSION
The evidence to date supports an association of SNHL with vitiligo. These results suggest audiologic assessment for early recognition and management of hearing loss in patients with vitiligo.
背景
白癜风是一种常见的色素脱失性疾病，由黑素细胞的自身免疫性破坏引起。一些证据表明黑素细胞参与了疾病过程中的听觉系统。然而，白癜风与感音神经性听力损失（SNHL）之间的关系仍不确定。
目的
我们研究了白癜风与SNHL之间的关联。
方法
在这项系统评价和荟萃分析中，检索了EMBASE、MEDLINE、PubMed和Cochrane数据库，以查找从创刊至2020年6月28日期间研究SNHL与白癜风之间关联的研究。
结果
共纳入14项病例对照研究，涉及938例白癜风患者。荟萃分析显示SNHL与白癜风之间存在显著关联（优势比[OR]为6.02[95%置信区间{CI}3.41-10.62]）。在调整研究质量和发表偏倚后，该关联仍然显著，OR分别为5.30（95%CI 1.53-18.35）和3.45（95%CI 1.75-6.81）。
局限性
听力损失的定义和测量方法不统一以及种族差异是潜在的偏倚来源。
结论
迄今为止的证据支持SNHL与白癜风之间存在关联。这些结果表明应对白癜风患者进行听力评估，以便早期识别和管理听力损失。
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