Sawaya R, Highsmith R
Department of Neurosurgery, University of Cincinnati College of Medicine, Ohio.
J Neurosurg. 1988 Jan;68(1):73-9. doi: 10.3171/jns.1988.68.1.0073.
Fresh human brain-tumor samples were assayed for their plasminogen activator (PA) content. Specific molecular weight patterns were identified for each of five common brain tumors and for normal brain, suggesting a cell-specific origin of the various PA forms. Malignant tumors contained higher PA activity and a larger number of molecular weight patterns than benign tumors, with the exception of acoustic neurinomas. Irradiated tumors contained lower PA activity than nonirradiated tumors. Finally, a slight but definite correlation between brain edema and PA activity was detected. The future role of brain-tumor PA's for diagnostic and therapeutic purposes is discussed.
对新鲜的人脑肿瘤样本进行了纤溶酶原激活剂（PA）含量测定。确定了五种常见脑肿瘤和正常脑的每种特定分子量模式，这表明各种PA形式具有细胞特异性起源。除听神经瘤外，恶性肿瘤比良性肿瘤含有更高的PA活性和更多的分子量模式。接受照射的肿瘤比未接受照射的肿瘤含有更低的PA活性。最后，检测到脑水肿与PA活性之间存在轻微但明确的相关性。讨论了脑肿瘤PA在诊断和治疗方面的未来作用。
