Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas, SP, Brazil.
Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas, SP, Brazil.
Microb Pathog. 2021 Jan;150:104696. doi: 10.1016/j.micpath.2020.104696. Epub 2020 Dec 28.
The DC subsets that express αE integrin (CD103) have been described to exert antagonistic functions, driving T cells towards either an inflammatory (Th1/Th17) or immunosuppressive phenotype (regulatory T cells - Treg). These functions depend on the tissue they reside and microenvironment factors or stimuli that this Antigen-presenting cell (APC) subpopulation receive. In this regard, immunoregulatory phenotype has been described in small subsets of CD103 DCs from lung and intestinal mucosa. The function of this APC subpopulation in pulmonary Paracoccidioides brasiliensis infection is poorly described. Here, we showed that lung CD103 DCs contribute to Treg differentiation in a pulmonary P. brasiliensis infection model, which was attributed to downregulation of costimulatory molecules analyzed in these APC subtypes 21 days post-infection. Overall, this data suggests that P. brasiliensis infection caused an immunosuppression that has also been observed in patients with the most severe form of Paracoccidioidomycosis (PCM) - a sickness caused by this fungus genus. Furthermore, these results open new perspectives for knowledge of the mechanisms that underlie the higher percentage of Treg cells found in peripheral blood of PCM patients.
表达 αE 整合素（CD103）的 DC 亚群已被描述为发挥拮抗作用，将 T 细胞推向炎症（Th1/Th17）或免疫抑制表型（调节性 T 细胞-Treg）。这些功能取决于它们所在的组织以及抗原呈递细胞（APC）亚群接收的微环境因素或刺激物。在这方面，肺和肠道黏膜中的 CD103 DC 的小亚群已被描述为具有免疫调节表型。在这里，我们表明，肺 CD103 DC 有助于肺巴西副球孢子菌感染中的 Treg 分化，这归因于感染后 21 天分析的这些 APC 亚型中共刺激分子的下调。总体而言，这些数据表明巴西副球孢子菌感染引起了免疫抑制，在最严重形式的副球孢子菌病（PCM）患者中也观察到了这种免疫抑制——一种由该真菌属引起的疾病。此外，这些结果为了解 PCM 患者外周血中发现的 Treg 细胞百分比较高的机制开辟了新的视角。
