Meng Fei
College of Food and Environmental Engineering, Chuzhou Vocational and Technical College, Chuzhou 239000, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2021 Mar 5;248:119233. doi: 10.1016/j.saa.2020.119233. Epub 2020 Nov 24.
The efficiency of singlet oxygen (O) can be subtly regulated by molecular alkyl chain length according to ΔE (the energy gap between S and T states). Which offer a strategy to adjust the O yield of photosensitizers (PSs) by molecular design strategy. Herein, three PSs (MZ1 ~ MZ3) were constructed of β-terpyridine derivatives, which possess different length alkyl chain (butyl, hexyl, and octyl group) with tunable O yield (3.366, 2.461 and 0.963). Based on studies that PSs with aggregation induced emission (AIE) characteristics showed effective emission intensity and high O yield. Subsequently, Photodynamic therapy (PDT) in vitro was further investigated. MZ1 showed relatively highest O yield, considerable cellular uptake and effective cell apoptosis upon light irradiation.
单线态氧（O）的效率可根据ΔE（S态和T态之间的能隙）通过分子烷基链长度进行精细调节。这提供了一种通过分子设计策略来调节光敏剂（PSs）单线态氧产率的方法。在此，三种PSs（MZ1~MZ3）由β-三联吡啶衍生物构建而成，它们具有不同长度的烷基链（丁基、己基和辛基），单线态氧产率可调（分别为3.366、2.461和0.963）。基于具有聚集诱导发光（AIE）特性的PSs表现出有效发射强度和高产率单线态氧的研究。随后，进一步研究了体外光动力疗法（PDT）。MZ1表现出相对最高的单线态氧产率、可观的细胞摄取以及光照后有效的细胞凋亡。
