State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan 430056, Hubei, PR China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China.
J Hazard Mater. 2021 Apr 5;407:124859. doi: 10.1016/j.jhazmat.2020.124859. Epub 2020 Dec 15.
Tetrabromobisphenol A (TBBPA) is a widely used flame retardant, but the adverse outcomes induced by TBBPA has not been fully elucidated. In this study, TBBPA was detected in 54.9% of 102 female Chinese volunteers with an average serum concentration of 0.34 ng/mL. To investigate whether TBBPA induces adverse outcomes at environmentally relevant exposure doses, the mice were exposed to TBBPA for 14 and 28 days. The internal doses of TBBPA in mice serum were nearly the internal doses in volunteers. TBBPA significantly increased the secretion of some pro-inflammatory cytokines and suppressed immune responses in mice under such serum concentrations after 14- and 28-days exposure. Interestingly, uterine edema was observed in TBBPA-treated mice. In primary uterine cells model, the results showed TBBPA exposure suppressed THRβ expression, leading to the activation of the inflammatory PI3K/NF-κB signaling pathway. Our findings indicated that the uterus is the susceptible target organ of TBBPA and TBBPA exposure might increase risk of uterine cancer through deregulating inflammation pathways.
四溴双酚 A（TBBPA）是一种广泛使用的阻燃剂，但 TBBPA 引起的不良后果尚未完全阐明。在这项研究中，在 102 名中国女性志愿者中，有 54.9%的人血清中检测到 TBBPA，平均浓度为 0.34ng/mL。为了研究 TBBPA 在环境相关暴露剂量下是否会引起不良后果，研究人员用 TBBPA 对小鼠进行了 14 天和 28 天的暴露。暴露后 14-28 天，小鼠血清中的 TBBPA 内剂量几乎与志愿者血清中的内剂量相同。TBBPA 显著增加了在这种血清浓度下的促炎细胞因子的分泌，并抑制了小鼠的免疫反应。有趣的是，TBBPA 处理的小鼠出现了子宫水肿。在原代子宫细胞模型中，结果表明 TBBPA 暴露抑制了 THRβ 的表达，导致炎症 PI3K/NF-κB 信号通路的激活。我们的研究结果表明，子宫是 TBBPA 的易感靶器官，TBBPA 暴露可能通过调节炎症途径增加患子宫癌的风险。
