胆囊收缩素拮抗剂。3-取代的1,4-苯并二氮杂䓬-2-胺的合成及生物学评价。 - Suppr

Suppr

超能文献

Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted 1,4-benzodiazepin-2-amines.

作者信息

Bock M G, DiPardo R M, Evans B E, Rittle K E, Freidinger R M, Chang R S, Lotti V J

机构信息

Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.

出版信息

J Med Chem. 1988 Jan;31(1):264-8. doi: 10.1021/jm00396a042.

DOI:10.1021/jm00396a042

PMID:3336026

Abstract

摘要

相似文献

Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted 1,4-benzodiazepin-2-amines.胆囊收缩素拮抗剂。3-取代的1,4-苯并二氮杂䓬-2-胺的合成及生物学评价。

J Med Chem. 1988 Jan;31(1):264-8. doi: 10.1021/jm00396a042.

Cholecystokinin antagonists. Synthesis and biological evaluation of 4-substituted 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines.胆囊收缩素拮抗剂。4-取代的4H-[1,2,4]三唑并[4,3-a][1,4]苯二氮䓬类化合物的合成与生物学评价。

J Med Chem. 1988 Jan;31(1):176-81. doi: 10.1021/jm00396a028.

Biological activity of analogues of YM022. Novel (3-amino substituted phenyl)urea derivatives of 1,4-benzodiazepin-2-one as gastrin/cholecystokinin-B receptor antagonists.YM022类似物的生物活性。新型1,4-苯并二氮杂卓-2-酮的（3-氨基取代苯基）脲衍生物作为胃泌素/胆囊收缩素-B受体拮抗剂。

Chem Pharm Bull (Tokyo). 1996 Jul;44(7):1412-4. doi: 10.1248/cpb.44.1412.

Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists.新型5-苯基-3-脲基-1,5-苯并二氮杂䓬类作为胆囊收缩素-B受体拮抗剂的合成与构效关系

J Med Chem. 2000 Oct 5;43(20):3596-613. doi: 10.1021/jm990967h.

Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom.基于κ-阿片受体激动剂替氟朵的胆囊收缩素-A受体配体。

J Med Chem. 1990 Jan;33(1):450-5. doi: 10.1021/jm00163a069.

Development of 1,4-benzodiazepine cholecystokinin type B antagonists.1,4-苯二氮䓬类胆囊收缩素B型拮抗剂的研发

J Med Chem. 1993 Dec 24;36(26):4276-92. doi: 10.1021/jm00078a018.

Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists.混合型胆囊收缩素（CCK）拮抗剂：CCK拮抗剂设计与修饰中的新启示

J Med Chem. 1989 Apr;32(4):739-42. doi: 10.1021/jm00124a003.

Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists.肽受体的非肽类配体设计：胆囊收缩素拮抗剂

J Med Chem. 1987 Jul;30(7):1229-39. doi: 10.1021/jm00390a019.

Selective non-peptide ligands for an accommodating peptide receptor. Imidazobenzodiazepines as potent cholecystokinin type B receptor antagonists.用于适应性肽受体的选择性非肽配体。咪唑并苯二氮䓬类作为强效的胆囊收缩素B型受体拮抗剂。

Bioorg Med Chem. 1994 Sep;2(9):987-98. doi: 10.1016/s0968-0896(00)82047-7.

Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.苯二氮卓类胃泌素和脑胆囊收缩素受体配体：L-365,260。

J Med Chem. 1989 Jan;32(1):13-6. doi: 10.1021/jm00121a004.

引用本文的文献

Synthesis of 3-aryl-2-phosphinoimidazo[1,2-]pyridine ligands for use in palladium-catalyzed cross-coupling reactions.用于钯催化交叉偶联反应的3-芳基-2-膦基咪唑并[1,2 -]吡啶配体的合成。

RSC Adv. 2019 Jun 5;9(31):17778-17782. doi: 10.1039/c9ra02200g. eCollection 2019 Jun 4.

Total synthesis of [Ψ[C(═S)NH]Tpg4]vancomycin aglycon, [Ψ[C(═NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding.[Ψ[C(═S)NH]Tpg4]万古霉素糖基、[Ψ[C(═NH)NH]Tpg4]万古霉素糖基及其相关关键化合物的全合成：为双重 D-Ala-D-Ala 和 D-Ala-D-Lac 结合而对万古霉素进行的工程改造。

J Am Chem Soc. 2012 Jan 18;134(2):1284-97. doi: 10.1021/ja209937s. Epub 2012 Jan 6.

Preparation of diazabicyclo[4.3.0]nonene-based peptidomimetics.基于二氮杂双环[4.3.0]壬烯的拟肽的制备。

J Org Chem. 2007 Aug 31;72(18):6865-72. doi: 10.1021/jo071074x. Epub 2007 Aug 8.

The use of receptor desensitization to analyse CCKA and CCKB/gastrin receptors coupled to contraction in guinea-pig stomach muscle.利用受体脱敏分析豚鼠胃肌中与收缩相关的CCKA和CCKB/胃泌素受体。

Br J Pharmacol. 1995 Jan;114(2):339-48. doi: 10.1111/j.1476-5381.1995.tb13232.x.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验