Marx M, Bettmann M A, Bridge S, Brodsky G, Boxt L M, Richie J P
Department of Surgery/Urology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
J Urol. 1988 Jan;139(1):180-5. doi: 10.1016/s0022-5347(17)42349-4.
In an attempt to objectively evaluate the biocompatibility of materials commonly used for ureteral stenting, stent-catheters made of four different materials were placed randomly in 31 ureters of 19 mongrel dogs. Animals underwent urography at four weeks and were sacrificed at six weeks. Mild hydronephrosis was noted in eight instances, essentially unrelated to specific material. Silicone, C-flex and polyurethane stents caused a similar, mild degree of ureteral edema, but ureters stented with Silitek demonstrated fairly marked edema. Epithelial ulceration and erosion, often severe, occurred with all polyurethane stents, and rarely with the three other materials. All materials differed statistically from controls, and C-flex caused less reaction overall than polyurethane, indicating differences in biocompatibility of the various materials which may be relevant to their use in patients undergoing long-term ureteral stenting. In practical terms, these suggest that certain materials, notably silicone and C-flex, are more suitable for ureteral stenting than others.
为客观评估常用于输尿管支架置入的材料的生物相容性，将由四种不同材料制成的支架导管随机置入19只杂种狗的31条输尿管中。动物在四周时接受尿路造影，并在六周时处死。八例出现轻度肾积水，基本与特定材料无关。硅胶、C-flex和聚氨酯支架引起相似程度的轻度输尿管水肿，但用Silitek支架置入的输尿管出现相当明显的水肿。所有聚氨酯支架均出现上皮溃疡和糜烂，且常较严重，而其他三种材料则很少出现。所有材料与对照组相比均有统计学差异，且C-flex总体引起的反应比聚氨酯少，表明各种材料的生物相容性存在差异，这可能与其在接受长期输尿管支架置入的患者中的应用有关。实际上，这些结果表明某些材料，尤其是硅胶和C-flex，比其他材料更适合用于输尿管支架置入。
