Weiss J S, Ellis C N, Headington J T, Tincoff T, Hamilton T A, Voorhees J J
Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.
JAMA. 1988;259(4):527-32.
In a 16-week randomized, double-blind, vehicle-controlled study of topical tretinoin in the treatment of photoaging, all patients applied topical tretinoin to one forearm and vehicle cream to the other. Half of the patients received tretinoin to the face, and half received vehicle cream. All 30 patients who completed the study showed statistically significant improvement in photoaging on the tretinoin-treated forearms, but not on the vehicle-treated forearms. Fourteen of the 15 patients who received tretinoin to the face had improvement in photoaging, whereas none of the vehicle-treated patients' faces improved, a statistically significant difference in response between the two groups. Statistically significant histologic changes were seen in forearm skin treated with tretinoin, but not with vehicle cream. Side effects were limited to irritation of tretinoin-exposed skin.
在一项为期16周的关于外用维甲酸治疗光老化的随机、双盲、赋形剂对照研究中，所有患者一只前臂涂抹外用维甲酸，另一只前臂涂抹赋形剂乳膏。一半患者面部涂抹维甲酸，另一半患者面部涂抹赋形剂乳膏。所有完成研究的30名患者中，接受维甲酸治疗的前臂光老化有统计学意义的显著改善，而接受赋形剂治疗的前臂则无改善。15名面部接受维甲酸治疗的患者中有14名光老化得到改善，而接受赋形剂治疗的患者面部均无改善，两组反应差异有统计学意义。在接受维甲酸治疗的前臂皮肤中可见有统计学意义的组织学变化，而赋形剂乳膏治疗的皮肤则无此变化。副作用仅限于维甲酸暴露皮肤的刺激。
