Kirchner J C, Edberg S C, Sasaki C T
Section of Otolaryngology, Yale University School of Medicine, New Haven, CT 06510.
Laryngoscope. 1988 Jan;98(1):26-9. doi: 10.1288/00005537-198801000-00007.
Systemic antibiotic therapy is widely used for prophylaxis in major head and neck surgery, but the efficacy of topical oral antibiotic therapy has not been adequately investigated. A pilot, placebo-controlled, double-blind crossover study using six healthy adult male volunteers was performed to assess the influence of topical clindamycin on oral flora. Samples of saliva were cultured for aerobic and anaerobic bacteria immediately before, and at 1- and 4-hour intervals after, rinsing the mouth with a solution of either placebo or clindamycin. Quantitative analysis demonstrated significantly reduced levels of both aerobic and anaerobic bacteria after use of the topical antibiotic at both the 1- and 4-hour intervals. It is postulated that topical clindamycin, by reducing concentrations of oral flora, may also reduce the incidence of regional infection following major upper aerodigestive tract surgery.
全身性抗生素治疗在头颈大手术的预防中广泛应用，但局部口服抗生素治疗的疗效尚未得到充分研究。一项使用6名健康成年男性志愿者的初步、安慰剂对照、双盲交叉研究，旨在评估局部使用克林霉素对口腔菌群的影响。在用安慰剂或克林霉素溶液漱口前、漱口后1小时和4小时间隔，采集唾液样本进行需氧菌和厌氧菌培养。定量分析表明，在1小时和4小时间隔使用局部抗生素后，需氧菌和厌氧菌水平均显著降低。据推测，局部使用克林霉素通过降低口腔菌群浓度，也可能降低上呼吸道消化道大手术后局部感染的发生率。
