碳酸酐酶抑制作用会影响直接刺激的大鼠比目鱼肌的收缩。

Carbonic anhydrase inhibition affects contraction of directly stimulated rat soleus.

作者信息

Geers C, Gros G

机构信息

Zentrum Physiologie, Medizinische Hochschule Hannover, Fed. Rep. Germany.

出版信息

Life Sci. 1988;42(1):37-45. doi: 10.1016/0024-3205(88)90622-4.

DOI:10.1016/0024-3205(88)90622-4

PMID:3336271

Abstract

We have studied the contractile parameters of directly stimulated isolated rat soleus muscles incubated in media containing the carbonic anhydrase inhibitors chlorzolamide (5.10(-4)M) or cyanate (10(-2)M). Both inhibitors caused a decrease in isometric twitch and tetanic (5s) tensions and an increase in muscle relaxation time. It is speculated that among the three types of skeletal muscle carbonic anhydrase it may be the enzyme associated with the sarcoplasmatic reticulum whose inhibition caused the observed changes in contractile parameters.

摘要

我们研究了在含有碳酸酐酶抑制剂氯唑酰胺（5×10⁻⁴M）或氰酸盐（10⁻²M）的培养基中孵育的直接刺激的离体大鼠比目鱼肌的收缩参数。两种抑制剂均导致等长收缩和强直（5秒）张力降低，以及肌肉松弛时间增加。据推测，在三种类型的骨骼肌碳酸酐酶中，可能是与肌浆网相关的酶，其抑制作用导致了观察到的收缩参数变化。