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BK virus-induced nephritis and cystitis after matched unrelated donor stem cell transplantation: A case report.匹配的无关供者干细胞移植后BK病毒引起的肾炎和膀胱炎：一例报告
Clin Case Rep. 2020 Sep 7;8(12):2839-2842. doi: 10.1002/ccr3.3246. eCollection 2020 Dec.
2
Full myeloablative conditioning and an unrelated HLA mismatched donor increase the risk for BK virus-positive hemorrhagic cystitis in allogeneic hematopoetic stem cell transplanted patients.清髓性预处理和非亲缘 HLA 不合供者增加异基因造血干细胞移植患者 BK 病毒阳性出血性膀胱炎的风险。
Anticancer Res. 2011 Mar;31(3):939-44.
3
BK virus nephropathy after allogeneic stem cell transplantation: a case report and literature review.异基因造血干细胞移植后BK病毒肾病：一例报告及文献复习
Am J Hematol. 2009 Apr;84(4):243-6. doi: 10.1002/ajh.21358.
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Late-onset hemorrhagic cystitis in children after hematopoietic stem cell transplantation for thalassemia and sickle cell anemia: a prospective evaluation of polyoma (BK) virus infection and treatment with cidofovir.儿童再生障碍性贫血和镰状细胞贫血造血干细胞移植后迟发性出血性膀胱炎：多瘤（BK）病毒感染的前瞻性评估和更昔洛韦治疗。
Biol Blood Marrow Transplant. 2010 May;16(5):662-71. doi: 10.1016/j.bbmt.2009.12.009. Epub 2009 Dec 22.
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Reactivation of polyomavirus in the genitourinary tract is significantly associated with severe GvHD and oral mucositis following allogeneic stem cell transplantation.在同种异体干细胞移植后，泌尿系统多瘤病毒的再激活与严重的移植物抗宿主病和口腔黏膜炎显著相关。
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Risk Assessment for BK Virus-Associated Hemorrhagic Cystitis After Pediatric Hematopoietic Stem Cell Transplant: A Single-Center Retrospective Cross-Sectional Study.儿童造血干细胞移植后BK病毒相关性出血性膀胱炎的风险评估：一项单中心回顾性横断面研究
Exp Clin Transplant. 2024 Nov;22(11):875-882. doi: 10.6002/ect.2021.0104. Epub 2021 Jun 17.
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BK Virus-associated Hemorrhagic Cystitis in Patients with Allogeneic Hematopoietic Cell Transplantation: Report of Three Cases.异基因造血细胞移植患者中BK病毒相关出血性膀胱炎：三例报告
Hematol Rep. 2017 Jun 26;9(2):7205. doi: 10.4081/hr.2017.7205. eCollection 2017 Jun 1.
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Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type.异基因造血干细胞移植后发生出血性膀胱炎是 BK 病毒感染、预处理方案强度和供者类型等多种因素复杂作用的结果。
Haematologica. 2010 Jul;95(7):1183-90. doi: 10.3324/haematol.2009.016758. Epub 2010 Apr 21.
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Beyond antivirals: virus-specific T-cell immunotherapy for BK virus haemorrhagic cystitis and JC virus progressive multifocal leukoencephalopathy.超越抗病毒药物：用于 BK 病毒出血性膀胱炎和 JC 病毒进行性多灶性白质脑病的病毒特异性 T 细胞免疫疗法。
Curr Opin Infect Dis. 2021 Dec 1;34(6):627-634. doi: 10.1097/QCO.0000000000000794.
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A related donor and reduced intensity conditioning reduces the risk of development of BK virus-positive haemorrhagic cystitis in allogeneic haematopoetic stem cell-transplanted patients.相关供体和减低强度预处理可降低异基因造血干细胞移植患者发生BK病毒阳性出血性膀胱炎的风险。
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引用本文的文献

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BK Polyomavirus Hemorrhagic Cystitis in Hematopoietic Cell Transplant Recipients.造血干细胞移植受者中的BK多瘤病毒出血性膀胱炎
J Glob Infect Dis. 2022 Feb 28;14(1):17-23. doi: 10.4103/jgid.jgid_139_21. eCollection 2022 Jan-Mar.

本文引用的文献

1
[Myelodysplastic syndrome, acute leukemia and stem cell transplantation].[骨髓增生异常综合征、急性白血病与干细胞移植]
Z Rheumatol. 2017 Oct;76(Suppl 2):26-32. doi: 10.1007/s00393-017-0369-2.
2
Intravesical cidofovir application in BK virus cystitis after allogeneic hematopoetic stem cell transplantation (HSCT) is safe and highly effective.异基因造血干细胞移植（HSCT）后膀胱内应用西多福韦治疗BK病毒膀胱炎安全且高效。
Bone Marrow Transplant. 2018 Apr;53(4):495-498. doi: 10.1038/s41409-017-0044-x. Epub 2018 Jan 12.
3
Are the Polyomaviruses BK and JC Associated with Opportunistic Infections, Graft-versus-Host Disease, or Worse Outcomes in Adult Patients Receiving Their First Allogeneic Stem Cell Transplantation with Low-Dose Alemtuzumab?多瘤病毒BK和JC是否与接受低剂量阿仑单抗首次异基因干细胞移植的成年患者的机会性感染、移植物抗宿主病或更差的预后相关？
Acta Haematol. 2017;138(1):3-9. doi: 10.1159/000468972. Epub 2017 Jun 8.
4
Acute Graft Host Disease: A Comprehensive Review.急性移植物抗宿主病：综述
Anticancer Res. 2017 Apr;37(4):1547-1555. doi: 10.21873/anticanres.11483.
5
Virucide properties of cold atmospheric plasma for future clinical applications.冷等离体子体的病毒杀灭特性及其未来的临床应用。
J Med Virol. 2017 Jun;89(6):952-959. doi: 10.1002/jmv.24701. Epub 2017 Feb 13.
6
An overview of infectious complications after allogeneic hematopoietic stem cell transplantation.异基因造血干细胞移植后感染性并发症概述。
J Infect Chemother. 2016 Aug;22(8):505-14. doi: 10.1016/j.jiac.2016.05.006. Epub 2016 Jun 22.
7
BK Virus in Kidney Transplant: Current Concepts, Recent Advances, and Future Directions.肾移植中的BK病毒：当前概念、最新进展及未来方向
Exp Clin Transplant. 2016 Aug;14(4):377-84. doi: 10.6002/ect.2016.0030. Epub 2016 Jun 3.
8
Urological Complications and BK Virus-Associated Diseases Under Allogenic Stem Cell Transplantation.
Urol Int. 2016;97(4):434-439. doi: 10.1159/000445124. Epub 2016 Mar 24.
9
BK virus nephropathy in renal transplant recipients.肾移植受者中的BK病毒肾病
Nephrology (Carlton). 2016 Aug;21(8):647-54. doi: 10.1111/nep.12728.
10
High burden of BK virus-associated hemorrhagic cystitis in patients undergoing allogeneic hematopoietic stem cell transplantation.异基因造血干细胞移植患者中 BK 病毒相关性出血性膀胱炎负担高。
Bone Marrow Transplant. 2014 May;49(5):664-70. doi: 10.1038/bmt.2013.235. Epub 2014 Feb 3.

匹配的无关供者干细胞移植后BK病毒引起的肾炎和膀胱炎：一例报告

BK virus-induced nephritis and cystitis after matched unrelated donor stem cell transplantation: A case report.

作者信息

Gelbrich Nadine, Stope Matthias B, Bekeschus Sander, Weigel Martin, Burchardt Martin, Zimmermann Uwe

机构信息

Department of Urology University Medicine Greifswald Greifswald Germany.

Department of Gynaecology and Gynaecological Oncology University Medicine Bonn Bonn Germany.

出版信息

Clin Case Rep. 2020 Sep 7;8(12):2839-2842. doi: 10.1002/ccr3.3246. eCollection 2020 Dec.

DOI:10.1002/ccr3.3246
PMID:33363833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7752429/
Abstract

Currently, there is no standard therapy for a BK virus infection of the urogenital tract in immunocompromised, stem cell transplanted patients, so that early diagnosis and introduction of supportive measures have the highest response rates to date.

摘要

目前，对于免疫功能低下的干细胞移植患者的泌尿生殖道BK病毒感染，尚无标准治疗方法，因此早期诊断并采取支持性措施是目前有效率最高的方法。