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氯吡格雷所致肝损伤：一例病例报告及文献复习

Clopidogrel-induced liver damage: A case report and review of the literature.

作者信息

Eslami Vahid, Gheymati Azin

机构信息

Shahid Beheshti University of Medical Sciences, Cardiovascular Research Center Tehran Iran.

Tehran University of Medical Sciences, School of Pharmacy Tehran Iran.

出版信息

Clin Case Rep. 2020 Sep 16;8(12):3024-3027. doi: 10.1002/ccr3.3324. eCollection 2020 Dec.

DOI:10.1002/ccr3.3324
PMID:33363872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7752642/
Abstract

Liver damage is a rare side effect of clopidogrel. That is reversible in most cases. Considering the widespread use of this medication in cardiovascular diseases, the management of hepatotoxicity requires further meticulous investigation.

摘要

肝损伤是氯吡格雷一种罕见的副作用，在大多数情况下是可逆的。鉴于这种药物在心血管疾病中的广泛应用，肝毒性的管理需要进一步细致研究。

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本文引用的文献

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Clopidogrel-Induced Severe Hepatitis: A Case Report and Literature Review.氯吡格雷诱发的严重肝炎：一例报告及文献综述
Case Reports Hepatol. 2016;2016:8068276. doi: 10.1155/2016/8068276. Epub 2016 Jun 27.
2
Drug-drug interactions between clopidogrel and novel cardiovascular drugs.氯吡格雷与新型心血管药物之间的药物相互作用。
Eur J Pharmacol. 2015 Oct 15;765:332-6. doi: 10.1016/j.ejphar.2015.08.059. Epub 2015 Sep 2.
3
Acute hepatitis associated with clopidogrel: a case report and review of the literature.氯吡格雷相关性急性肝炎：一例病例报告及文献复习
Am J Ther. 2015 Jan-Feb;22(1):e8-e13. doi: 10.1097/MJT.0b013e318293b0d6.
4
Significant increase in clopidogrel use across U.S. children's hospitals.
Pediatr Cardiol. 2011 Feb;32(2):167-75. doi: 10.1007/s00246-010-9836-0. Epub 2010 Dec 7.
5
Fatal liver injury associated with clopidogrel.氯吡格雷相关致死性肝损伤。
Fundam Clin Pharmacol. 2010 Aug;24(4):433-5. doi: 10.1111/j.1472-8206.2009.00791.x. Epub 2009 Nov 5.
6
Why is the use of clopidogrel increasing rapidly in Australia? An exploration of geographical location, age, sex and cardiac stenting rates as possible influences on clopidogrel use.为什么氯吡格雷在澳大利亚的使用量迅速增加？探讨地理位置、年龄、性别和心脏支架置入率对氯吡格雷使用可能产生的影响。
Pharmacoepidemiol Drug Saf. 2008 Nov;17(11):1077-90. doi: 10.1002/pds.1638.
7
Clinico-histopathological characteristics of clopidogrel-induced hepatic injury: case report and review of literature.氯吡格雷所致肝损伤的临床病理特征：病例报告及文献复习
Eur J Gastroenterol Hepatol. 2006 Aug;18(8):931-4. doi: 10.1097/00042737-200608000-00022.
8
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.对乙酰氨基酚所致急性肝衰竭：一项美国多中心前瞻性研究的结果
Hepatology. 2005 Dec;42(6):1364-72. doi: 10.1002/hep.20948.
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Ann Intern Med. 2002 Dec 17;137(12):947-54. doi: 10.7326/0003-4819-137-12-200212170-00007.
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