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Vismodegib dose reduction effective when combined with itraconazole for the treatment of advanced basal cell carcinoma.

作者信息

Yoon Jaeyoung

机构信息

Yoon Dermatology, Wentzville, Missouri.

出版信息

JAAD Case Rep. 2020 Nov 24;7:107-109. doi: 10.1016/j.jdcr.2020.11.014. eCollection 2021 Jan.

DOI:10.1016/j.jdcr.2020.11.014
PMID:33364281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7750706/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8268/7750706/21aa98944153/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8268/7750706/abc570c38e11/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8268/7750706/21aa98944153/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8268/7750706/abc570c38e11/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8268/7750706/21aa98944153/gr2.jpg

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JAAD Case Rep. 2020 Nov 24;7:107-109. doi: 10.1016/j.jdcr.2020.11.014. eCollection 2021 Jan.
2
A comprehensive review of the role of the hedgehog pathway and vismodegib in the management of basal cell carcinoma.对刺猬信号通路及维莫德吉在基底细胞癌治疗中作用的全面综述。
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Vismodegib: an inhibitor of the Hedgehog signaling pathway in the treatment of basal cell carcinoma.维莫德吉：一种用于治疗基底细胞癌的刺猬信号通路抑制剂。
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Vismodegib, itraconazole and sonidegib as hedgehog pathway inhibitors and their relative competencies in the treatment of basal cell carcinomas.维莫德吉、伊曲康唑和索尼德吉作为刺猬信号通路抑制剂及其在治疗基底细胞癌方面的相对效能。
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本文引用的文献

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Triazoles bind the C-terminal domain of SMO: Illustration by docking and molecular dynamics simulations the binding between SMO and triazoles.三氮唑与 SMO 的 C 端结构域结合：通过对接和分子动力学模拟阐明 SMO 与三氮唑的结合。
Life Sci. 2019 Jan 15;217:222-228. doi: 10.1016/j.lfs.2018.12.012. Epub 2018 Dec 10.
2
Intracranial regression of an advanced basal cell carcinoma using sonidegib and itraconazole after failure with vismodegib.维莫德吉治疗失败后，使用索尼德吉和伊曲康唑使晚期基底细胞癌颅内病灶消退
JAAD Case Rep. 2017 Dec 18;4(1):10-12. doi: 10.1016/j.jdcr.2017.11.001. eCollection 2018 Jan.
3
Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.
维莫德吉治疗晚期基底细胞癌患者的长期安全性和有效性：关键ERIVANCE BCC研究的最终更新
BMC Cancer. 2017 May 16;17(1):332. doi: 10.1186/s12885-017-3286-5.
4
Thoughts on investigational hedgehog pathway inhibitors for the treatment of cancer.关于用于治疗癌症的研究性刺猬信号通路抑制剂的思考
Expert Opin Investig Drugs. 2017 Feb;26(2):133-136. doi: 10.1080/13543784.2017.1274392. Epub 2016 Dec 27.
5
Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the U.S. Population, 2012.美国 2012 年人群中非黑色素瘤皮肤癌（角质形成细胞癌）的发病率估计。
JAMA Dermatol. 2015 Oct;151(10):1081-6. doi: 10.1001/jamadermatol.2015.1187.
6
Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma.开放性、探索性 II 期临床试验：口服伊曲康唑治疗基底细胞癌。
J Clin Oncol. 2014 Mar 10;32(8):745-51. doi: 10.1200/JCO.2013.49.9525. Epub 2014 Feb 3.
7
Efficacy and safety of vismodegib in advanced basal-cell carcinoma.维莫德吉治疗晚期基底细胞癌的疗效和安全性。
N Engl J Med. 2012 Jun 7;366(23):2171-9. doi: 10.1056/NEJMoa1113713.
8
Pharmacokinetic dose-scheduling study of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors. hedgehog 通路抑制剂维莫德吉（GDC-0449）在局部晚期或转移性实体瘤患者中的药代动力学剂量调整研究。
Clin Cancer Res. 2011 Sep 1;17(17):5774-82. doi: 10.1158/1078-0432.CCR-11-0972. Epub 2011 Jul 13.
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Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector.砷通过阻止纤毛积累和降低Gli2 转录效应物的稳定性来拮抗 Hedgehog 通路。
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13432-7. doi: 10.1073/pnas.1006822107. Epub 2010 Jul 12.
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Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.伊曲康唑，一种常用的抗真菌药物，可抑制 Hedgehog 通路活性和肿瘤生长。
Cancer Cell. 2010 Apr 13;17(4):388-99. doi: 10.1016/j.ccr.2010.02.027.