Jia Tian, Wang Chen, Han Zhengxi, Wang Xiaozhi, Ding Ming, Wang Quanyi
School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
School of Pharmacy, China Pharmaceutical University, Nanjing, China.
Front Cardiovasc Med. 2020 Dec 7;7:588075. doi: 10.3389/fcvm.2020.588075. eCollection 2020.
Cardiovascular diseases, as the most common non-communicable disease in the world, cause a high mortality rate today and bring a serious medical burden to countries worldwide, especially in low- and middle-income countries. Experimental rodent models are widely used for cardiovascular diseases researches due to the effective simulation of human cardiovascular diseases, strong reproductive ability, and easy detection. Herein, we will summarize the pathological manifestations of common cardiovascular diseases and illustrate the establishment of corresponding experimental rodent models in detail.
心血管疾病作为全球最常见的非传染性疾病，如今导致了很高的死亡率，并给世界各国，尤其是低收入和中等收入国家带来了沉重的医疗负担。实验性啮齿动物模型由于能有效模拟人类心血管疾病、繁殖能力强且易于检测，而被广泛用于心血管疾病研究。在此，我们将总结常见心血管疾病的病理表现，并详细阐述相应实验性啮齿动物模型的建立。
