致编辑的信：“青春期早熟和多囊卵巢综合征中的糖皮质激素抵抗：从儿童期到成年期”
Letter to the Editor: "Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood".
作者信息
Rosenfield Robert L
机构信息
The University of Chicago, Pritzker School of Medicine, Departments of Medicine and Pediatrics, Section of Endocrinology, Metabolism, and Diabetes, Chicago, Illinois.
The University of California, San Francisco, Pediatric Endocrinology, San Francisco, California.
出版信息
J Endocr Soc. 2020 Nov 7;5(1):bvaa163. doi: 10.1210/jendso/bvaa163. eCollection 2021 Jan 1.
Abstract
The conclusion of Panayiotopoulos that glucocorticoid resistance accounted for 57% to 67% of their premature adrenarche and polycystic ovary syndrome cases cannot be accepted from the data presented. This is because proper validation of their method for determining glucocorticoid sensitivity is not presented. Furthermore, the method seems insensitive to physiologic glucocorticoid concentrations.
摘要
帕纳约托普洛斯得出结论，认为糖皮质激素抵抗占其性早熟和多囊卵巢综合征病例的57%至67%，但从所提供的数据来看，这一结论无法成立。这是因为他们未对测定糖皮质激素敏感性的方法进行适当验证。此外，该方法似乎对生理性糖皮质激素浓度不敏感。
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