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Albumin Supplementation Dampens Hypercoagulability in COVID-19: A Preliminary Report.补充白蛋白可减轻 COVID-19 患者的高凝状态：初步报告。
Thromb Haemost. 2021 Jan;121(1):102-105. doi: 10.1055/s-0040-1721486. Epub 2020 Dec 23.
2
Hypocalcemia and hypoalbuminemia during COVID-19 infection: Opportunities for therapeutic intervention.新冠病毒感染期间的低钙血症和低白蛋白血症：治疗干预的机会
J Infect Public Health. 2020 Dec;13(12):1887. doi: 10.1016/j.jiph.2020.09.019. Epub 2020 Oct 10.
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Direct Application of 3-Maleimido-PROXYL for Proving Hypoalbuminemia in Cases of SARS-CoV-2 Infection: The Potential Diagnostic Method of Determining Albumin Instability and Oxidized Protein Level in Severe COVID-19.直接应用 3-马来酰亚胺基-PROXYL 证明 SARS-CoV-2 感染病例中的低白蛋白血症：确定严重 COVID-19 中白蛋白不稳定性和氧化蛋白水平的潜在诊断方法。
Int J Mol Sci. 2023 Mar 18;24(6):5807. doi: 10.3390/ijms24065807.
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Reply to "High frequency of Antiphospholipid Antibodies in Critically ill COVID-19 patients: a Link with Hypercoagulability?".对《危重症 COVID-19 患者中抗磷脂抗体的高频率：与高凝状态有关联？》的回复
J Intern Med. 2021 Mar;289(3):425-426. doi: 10.1111/joim.13159. Epub 2020 Sep 9.
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Regarding: Hypoalbuminemia in COVID-19.关于：新型冠状病毒肺炎中的低白蛋白血症
J Intern Med. 2022 Mar;291(3):388-389. doi: 10.1111/joim.13403. Epub 2021 Nov 15.
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Current Overview on Hypercoagulability in COVID-19.新型冠状病毒肺炎患者高凝状态的研究现状。
Am J Cardiovasc Drugs. 2020 Oct;20(5):393-403. doi: 10.1007/s40256-020-00431-z.
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Better Anticoagulated Than Not! Hypercoagulability in COVID-19.抗凝好过不抗凝！新型冠状病毒肺炎中的高凝状态。
JCO Oncol Pract. 2021 Sep;17(9):522-523. doi: 10.1200/OP.21.00359. Epub 2021 Jun 16.
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COVID-19 and hypercoagulability in the outpatient setting.门诊环境中的2019冠状病毒病与高凝状态
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Hypercoagulability following COVID-19 infection: at what stage is it safe to do a free flap?新型冠状病毒肺炎感染后的高凝状态：进行游离皮瓣手术在哪个阶段是安全的？
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Rotational thromboelastometry to assess hypercoagulability in COVID-19 patients.采用旋转血栓弹力图评估新型冠状病毒肺炎患者的高凝状态。
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引用本文的文献

1
Preoperative albumin can predict the risk of postoperative deep venous thrombosis in non-cardiac surgery.术前白蛋白可预测非心脏手术患者术后深静脉血栓形成的风险。
Front Med (Lausanne). 2025 Aug 21;12:1635218. doi: 10.3389/fmed.2025.1635218. eCollection 2025.
2
Albumin: A Review of Market Trends, Purification Methods, and Biomedical Innovations.白蛋白：市场趋势、纯化方法及生物医学创新综述
Curr Issues Mol Biol. 2025 Apr 26;47(5):303. doi: 10.3390/cimb47050303.
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Impact of Early Administration of Albumin on Mortality Among Severe COVID-19 Patients, China.早期给予白蛋白对中国重症 COVID-19 患者死亡率的影响
Infect Drug Resist. 2025 Mar 19;18:1539-1549. doi: 10.2147/IDR.S510245. eCollection 2025.
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Association between the lowest level of serum albumin during hospitalization and adverse outcomes in older adults with COVID-19.住院期间血清白蛋白最低水平与 COVID-19 老年患者不良结局的关联。
Medicine (Baltimore). 2024 Nov 29;103(48):e40734. doi: 10.1097/MD.0000000000040734.
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Association Between NOX2-Mediated Oxidative Stress, Low-Grade Endotoxemia, Hypoalbuminemia, and Clotting Activation in COVID-19.COVID-19中NOX2介导的氧化应激、低度内毒素血症、低白蛋白血症与凝血激活之间的关联
Antioxidants (Basel). 2024 Oct 17;13(10):1260. doi: 10.3390/antiox13101260.
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Hypoalbuminemia and Risk of Portal Vein Thrombosis in Cirrhosis.肝硬化患者低白蛋白血症与门静脉血栓形成风险
Gastro Hep Adv. 2024 Mar 13;3(5):646-653. doi: 10.1016/j.gastha.2024.03.006. eCollection 2024.
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Blood-derived product therapies for SARS-CoV-2 infection and long COVID.用于治疗SARS-CoV-2感染和长期新冠的血液衍生产品疗法。
MedComm (2020). 2023 Nov 15;4(6):e426. doi: 10.1002/mco2.426. eCollection 2023 Dec.
8
Enhanced recellularization by using albumin coating with roller bottle cell culture.通过在转瓶细胞培养中使用白蛋白包被来增强细胞再植。
Regen Ther. 2023 Oct 31;24:568-573. doi: 10.1016/j.reth.2023.10.002. eCollection 2023 Dec.
9
Serum Albumin Levels: A Biomarker to Be Repurposed in Different Disease Settings in Clinical Practice.血清白蛋白水平：一种可在临床实践中用于不同疾病背景下重新定位的生物标志物。
J Clin Med. 2023 Sep 17;12(18):6017. doi: 10.3390/jcm12186017.
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D-dimer-albumin ratio (DAR) as a new biomarker for predicting preoperative deep vein thrombosis after geriatric hip fracture patients.D-二聚体-白蛋白比值（DAR）作为预测老年髋部骨折患者术后深静脉血栓的新型生物标志物。
J Orthop Surg Res. 2023 Aug 31;18(1):645. doi: 10.1186/s13018-023-04139-z.

本文引用的文献

1
Laboratory parameters in patients with COVID-19 on first emergency admission is different in non-survivors: albumin and lactate dehydrogenase as risk factors.首次急诊入院的 COVID-19 患者的实验室参数在非幸存者中有所不同：白蛋白和乳酸脱氢酶是危险因素。
J Clin Pathol. 2021 Oct;74(10):673-675. doi: 10.1136/jclinpath-2020-206865. Epub 2020 Oct 6.
2
D-dimer levels on admission and all-cause mortality risk in COVID-19 patients: a meta-analysis.入院时 D-二聚体水平与 COVID-19 患者全因死亡率的关系：一项荟萃分析。
Epidemiol Infect. 2020 Sep 7;148:e202. doi: 10.1017/S0950268820002022.
3
Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series.华盛顿州致命性 COVID-19 感染的组织病理学和超微结构发现：病例系列研究。
Lancet. 2020 Aug 1;396(10247):320-332. doi: 10.1016/S0140-6736(20)31305-2. Epub 2020 Jul 16.
4
Is Albumin Predictor of Mortality in COVID-19?白蛋白是新冠病毒肺炎患者死亡率的预测指标吗？
Antioxid Redox Signal. 2021 Jul 10;35(2):139-142. doi: 10.1089/ars.2020.8142. Epub 2020 Jun 22.
5
Hypoalbuminemia, Coagulopathy, and Vascular Disease in COVID-19.新型冠状病毒肺炎中的低白蛋白血症、凝血功能障碍和血管疾病
Circ Res. 2020 Jul 17;127(3):400-401. doi: 10.1161/CIRCRESAHA.120.317173. Epub 2020 Jun 8.
6
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.新型冠状病毒肺炎的肺血管内皮细胞炎症、血栓形成和血管生成。
N Engl J Med. 2020 Jul 9;383(2):120-128. doi: 10.1056/NEJMoa2015432. Epub 2020 May 21.
7
Association of Treatment Dose Anticoagulation With In-Hospital Survival Among Hospitalized Patients With COVID-19.新冠病毒肺炎住院患者治疗剂量抗凝与院内生存的相关性
J Am Coll Cardiol. 2020 Jul 7;76(1):122-124. doi: 10.1016/j.jacc.2020.05.001. Epub 2020 May 6.
8
Hypercoagulation and Antithrombotic Treatment in Coronavirus 2019: A New Challenge.2019 年冠状病毒病的高凝和抗血栓治疗：新的挑战。
Thromb Haemost. 2020 Jun;120(6):949-956. doi: 10.1055/s-0040-1710317. Epub 2020 Apr 29.
9
D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19.入院时 D-二聚体水平预测 COVID-19 患者住院死亡率。
J Thromb Haemost. 2020 Jun;18(6):1324-1329. doi: 10.1111/jth.14859.
10
Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19.重症新型冠状病毒肺炎中肺血栓形成现象的病理学证据
J Thromb Haemost. 2020 Jun;18(6):1517-1519. doi: 10.1111/jth.14844.

Albumin Supplementation Dampens Hypercoagulability in COVID-19: A Preliminary Report.

作者信息

Violi Francesco, Ceccarelli Giancarlo, Loffredo Lorenzo, Alessandri Francesco, Cipollone Francesco, D'ardes Damiano, D'Ettorre Gabriella, Pignatelli Pasquale, Venditti Mario, Mastroianni Claudio Maria, Pugliese Francesco

机构信息

I Clinica Medica, Department of Clinical Internal, Anaesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.

出版信息

Thromb Haemost. 2021 Jan;121(1):102-105. doi: 10.1055/s-0040-1721486. Epub 2020 Dec 23.

DOI:10.1055/s-0040-1721486
PMID:33368057
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7869060/
Abstract
摘要