Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Department of Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, China.
HIV Med. 2020 Dec;21(11):718-721. doi: 10.1111/hiv.13026.
To investigate the seroreversion time in HIV-1-exposed but uninfected infants from two tertiary hospitals in China.
This study retrospectively investigated the data of perinatal, HIV-1-exposed infants from hospitals in Beijing and Shenzhen. Maternal and infant medical records from both hospitals from January 2009 to December 2019 were reviewed, and the HIV antibody seroreversion times of infants were determined. From 2009 to 2019, a total of 485 HIV-1-exposed but uninfected infants were enrolled. The majority of infants were born at term with normal birth weight.
The seroreversion rates were 89.3%, 94.2% and 100% at 12, 18 and 24 months of age, respectively. There were no significant associations between seroreversion and several risk factors, such as gender, birth weight, gestational age, mode of delivery, postpartum prophylaxis and antiretroviral treatment duration. The mean value of HIV-specific immunoglobulin G concentration decreased from 15.4 at day 42 to 0.03 after 24 months in HIV-exposed, uninfected infants.
Clearance of HIV antibodies could take more than 18 months in a small number of perinatally exposed infants. Caution should be used in excluding or diagnosing perinatal HIV infection in children with long persistence of HIV antibodies.
调查中国两家三级医院中 HIV-1 暴露但未感染婴儿的血清学转换时间。
本研究回顾性调查了来自北京和深圳医院的围产期 HIV-1 暴露婴儿的数据。对来自这两家医院的母婴病历进行了回顾，并确定了婴儿的 HIV 抗体血清学转换时间。2009 年至 2019 年，共纳入 485 名 HIV-1 暴露但未感染的婴儿。大多数婴儿足月出生，体重正常。
12、18 和 24 个月时的血清学转化率分别为 89.3%、94.2%和 100%。血清学转换与性别、出生体重、胎龄、分娩方式、产后预防和抗逆转录病毒治疗持续时间等几个风险因素之间无显著关联。HIV 暴露但未感染婴儿的 HIV 特异性免疫球蛋白 G 浓度从 42 天的 15.4 平均值下降到 24 个月后的 0.03。
在少数围产期暴露的婴儿中，清除 HIV 抗体可能需要 18 个月以上。对于 HIV 抗体持续存在时间较长的儿童，应谨慎排除或诊断围产期 HIV 感染。
