[血流动力学优化在人工心脏设计中的应用]
[Application of hemodynamic optimization in the design of artificial heart].
作者信息
Fu Minrui, Gao Bin, Chang Yu, Liu Youjun
机构信息
Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, P.R.China.
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2020 Dec 25;37(6):1000-1011. doi: 10.7507/1001-5515.202008080.
Heart failure is one kind of cardiovascular disease with high risk and high incidence. As an effective treatment of heart failure, artificial heart is gradually used in clinical treatment. Blood compatibility is an important parameter or index of artificial heart, and how to evaluate it through hemodynamic design and hemolysis test is a research hotspot in the industry. This paper first reviews the research progress in hemodynamic optimization and hemolysis evaluation of artificial heart, and then introduces the research achievements and progress of the team in related fields. The hemodynamic performance of the blood pump optimized in this paper can meet the needs of use. The normalized index of hemolysis obtained by in standard vitro hemolysis test is less than 0.1 g/100 L, which has good hemolysis performance . The optimization method described in this paper is suitable for most of the development of blood pump and can provide reference for related research work.
心力衰竭是一种高风险、高发病率的心血管疾病。作为心力衰竭的一种有效治疗手段，人工心脏逐渐应用于临床治疗。血液相容性是人工心脏的一个重要参数或指标，如何通过血流动力学设计和溶血试验对其进行评估是该行业的一个研究热点。本文首先综述了人工心脏血流动力学优化和溶血评估的研究进展，然后介绍了团队在相关领域的研究成果和进展。本文优化后的血泵血流动力学性能能够满足使用需求。在标准体外溶血试验中获得的溶血归一化指标小于0.1g/100L，具有良好的溶血性能。本文所述的优化方法适用于大多数血泵的研发，可为相关研究工作提供参考。
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