高膳食铁和抗坏血酸对缺铜和铜充足大鼠铜状态的不良影响。

Adverse effects of high dietary iron and ascorbic acid on copper status in copper-deficient and copper-adequate rats.

作者信息

Johnson M A, Murphy C L

机构信息

Department of Foods and Nutrition, University of Georgia, Athens 30602.

出版信息

Am J Clin Nutr. 1988 Jan;47(1):96-101. doi: 10.1093/ajcn/47.1.96.

DOI:10.1093/ajcn/47.1.96

PMID:3337044

Abstract

The effects of elevated dietary ascorbic acid and iron on copper utilization were examined. Male Sprague-Dawley rats were fed one of two levels of Cu (deficient, 0.42 microgram Cu/g, or adequate, 5.74 micrograms Cu/g), Fe (moderate, 38 micrograms Fe/g or high, 191 micrograms Fe/g), and ascorbic acid (low, 0% or high, 1% of the diet) for 20 d. High Fe decreased (p less than 0.05) Cu absorption only in Cu-deficient rats. High ascorbic acid significantly decreased tissue Cu levels in Cu-adequate rats. High Fe with ascorbic acid caused severe anemia in Cu-deficient rats and decreased plasma ceruloplasmin by 44% in Cu-adequate rats. Cu,Zn-superoxide dismutase activity in erythrocytes was decreased (p less than 0.05) by 14% during Cu deficiency but was not affected by Fe or ascorbic acid. These results may be important to individuals with high intakes of Fe and ascorbic acid.

摘要

研究了膳食中抗坏血酸和铁含量升高对铜利用的影响。将雄性斯普拉格-道利大鼠分为两组，分别喂食两种铜水平（缺乏组，0.42微克铜/克；充足组，5.74微克铜/克）、两种铁水平（中等组，38微克铁/克；高剂量组，191微克铁/克）以及两种抗坏血酸水平（低剂量组，占饮食的0%；高剂量组，占饮食的1%），持续20天。高剂量铁仅在缺铜大鼠中降低了（p<0.05）铜的吸收。高剂量抗坏血酸显著降低了铜充足大鼠的组织铜水平。高剂量铁与抗坏血酸共同作用导致缺铜大鼠出现严重贫血，并使铜充足大鼠的血浆铜蓝蛋白降低了44%。在铜缺乏期间，红细胞中的铜锌超氧化物歧化酶活性降低了（p<0.05）14%，但不受铁或抗坏血酸的影响。这些结果对于铁和抗坏血酸摄入量高的个体可能具有重要意义。