Department of Forensic Medicine, Tokai University School of Medicine, Kanagawa, Japan; Tokyo Medical Examiner's Office, Tokyo, Japan.
Tokyo Medical Examiner's Office, Tokyo, Japan.
Leg Med (Tokyo). 2021 Feb;48:101831. doi: 10.1016/j.legalmed.2020.101831. Epub 2020 Dec 25.
Cardiac hypertrophy is a clinical risk factor for cardiovascular death (CVD) frequently recorded in autopsy reports, but the diagnostic criteria for the condition have not been clearly-established for autopsy. This study aimed to estimate the cutoff value for hypertrophic heart weight that can efficiently assist the postmortem diagnosis of CVD.
We analyzed accumulated autopsy data from 3534 individuals aged 0-101 years.
We found that heart weight increased linearly with a person's age until 20 years, after which it remained stable. The mean heart weight in CVD cases was 473 g in men and 379 g in women. The mean heart weight in non-CVD cases was 385 g in men and 320 g in women. Receiver operating characteristic curve analysis for CVD assessment revealed that the cutoff value of heart weight was 407 g (odds ratio of 4.2) in men and 327 g (2.6) in women, and that of heart weight/body height was 2.38 g/cm (4.0) in men and 2.15 g/cm (2.6) in women, respectively. Overall, heart weight was a more useful predictor of CVD in men than in women. In logistic regression analysis, the predictive power of heart weight for CVD was higher than that of body mass index in both sexes.
Thus, the criteria for hypertrophic heart weight are practical and useful for autopsy recordings, and it can be helpful for postmortem diagnosis of CVD. Our report is the first to reveal the cutoff value for hypertrophic heart weight in the Japanese population.
心脏肥大是尸检报告中经常记录的心血管死亡（CVD）的临床危险因素，但心脏肥大的诊断标准在尸检中尚未明确。本研究旨在评估有助于 CVD 死后诊断的心脏肥大重量的截止值。
我们分析了来自 3534 名 0-101 岁个体的尸检数据。
我们发现心脏重量随年龄线性增加，直到 20 岁，之后保持稳定。CVD 病例的平均心脏重量为男性 473g，女性 379g。非 CVD 病例的平均心脏重量为男性 385g，女性 320g。CVD 评估的受试者工作特征曲线分析显示，男性心脏重量的截止值为 407g（优势比为 4.2），女性为 327g（2.6），心脏重量/身高的截止值为男性 2.38g/cm（4.0），女性为 2.15g/cm（2.6）。总体而言，心脏重量是男性 CVD 的更有用预测指标。在逻辑回归分析中，心脏重量对 CVD 的预测能力在两性中均高于体重指数。
因此，心脏肥大重量的标准对于尸检记录是实用和有用的，并且可以帮助 CVD 的死后诊断。我们的报告首次揭示了日本人群中心脏肥大重量的截止值。
