在乳腺和乳腺外派杰病中表达脂肪瘤偏好伴侣。
Expression of lipoma preferred partner in mammary and extramammary Paget disease.
机构信息
Department of Breast Surgery, The First Affiliated Hospital of China Medical University.
Department of Dermatology, The First Hospital of China Medical University, Heping District, Shenyang, Liaoning Province, P.R. China.
出版信息
Medicine (Baltimore). 2020 Dec 18;99(51):e23443. doi: 10.1097/MD.0000000000023443.
BACKGOUND
This study aims to identify the expression of lipoma preferred partner (LPP) in Paget disease (PD) and to further understand the pathogenesis of PD.
METHODS
Tissue microarray was used to evaluate the expression of LPP by immunohistochemistry in 40 PD patients. The results of LPP expression were combined with clinical and histopathological characteristics. Patient files were analyzed retrospectively.
RESULTS
Twenty-one cases were mammary Paget disease (MPD) and 19 extramammary Paget disease (EMPD) involving the vulva, scrotum, and penis. LPP was expressed in PD and this expression was significantly greater in MPD versus EMPD (P = .031). The expression of LPP in MPD was significantly related with age (P = .009) and expression of Ki-67 (P = .011). No statistically significant differences were observed in LPP expression as related to sex, body location, and time of PD diagnosis.
CONCLUSIONS
While LPP is expressed in both MPD and EMPD, the intensity of this expression is greater in MPD. LPP expression is positively correlated with Ki-67 and is more prevalent in middle-aged versus senior MPD patients. Further research is needed to determine its potential role in tumorigenesis and distribution.
背景
本研究旨在鉴定脂肪母细胞瘤优先伙伴（LPP）在Pagets 病（PD）中的表达，并进一步了解 PD 的发病机制。
方法
应用组织微阵列，通过免疫组织化学方法检测 40 例 PD 患者中 LPP 的表达。将 LPP 表达的结果与临床和组织病理学特征相结合。对患者的病历进行回顾性分析。
结果
21 例为乳腺 Pagets 病（MPD），19 例为乳腺外 Pagets 病（EMPD），累及外阴、阴囊和阴茎。PD 中表达 LPP，MPD 中的表达明显高于 EMPD（P=0.031）。MPD 中 LPP 的表达与年龄（P=0.009）和 Ki-67 的表达（P=0.011）显著相关。LPP 的表达与性别、身体部位和 PD 诊断时间无统计学差异。
结论
虽然 LPP 在 MPD 和 EMPD 中均有表达，但在 MPD 中表达强度更高。LPP 的表达与 Ki-67 呈正相关，在中年 MPD 患者中比老年患者更为常见。需要进一步研究以确定其在肿瘤发生和分布中的潜在作用。
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