Toropygin S G, Mayorova E V, Maslov A N, Budzinskaya M V
Tver State Medical University, Tver, Russia.
Research Institute of Eye Diseases, Moscow, Russia.
Vestn Oftalmol. 2020;136(6. Vyp. 2):133-141. doi: 10.17116/oftalma2020136062133.
The search for optimal design and material of the intraocular lens (IOL) that would prevent posterior capsule opacification (PCO) is still a relevant problem.
To compare the influence of three models of hydrophobic acrylic IOLs on the development of PCO within one year after phaco surgery.
The study included 72 patients (91 eyes) who were followed up for 12 months after implantation of one of three models of posterior chamber hydrophobic acrylic IOLs: MIOL-2 (Reper-NN, Russia, 24 eyes, 1 group), SA60AT and US60MP (Alcon, USA, 41 and 26 eyes, 2 and 3 groups, respectively). Posterior capsule images were taken and then processed with the EPCO 2000 (Evaluation of Posterior Capsular Opacification) software. The area of posterior capsule adjacent to the center of IOL's optic of 4.0 mm in diameter was estimated. PCO score was calculated as the weighted sum of opacification areas multiplied by the degree (from 0 to 4).
Within 1 year of the follow-up, mean visual acuity was at least 1.0 (20/20). Significant PCO progression was observed as early as 3 months after surgery. Despite that, opacification density in all three groups at every follow-up visit did not exceed grade 2; maximal PCO score (0.0315, median) was seen 12 month after surgery in the 1 group. At the same time, differences in PCO score between the groups were not significant. Nd:YAG laser posterior capsulotomy was performed only in one patient from the 1 group 12 month after surgery. Difference in the percentage of clear posterior capsules was significant only 12 month after surgery between the 1 and 3 groups (=0.024).
All three models of hydrophobic acrylic IOLs showed comparably high vision outcomess during 12 months of the follow-up with somewhat better PCO score and percentage of clear posterior capsules in eyes with US60MP.
寻找能够预防后囊膜混浊(PCO)的人工晶状体(IOL)的最佳设计和材料仍然是一个相关问题。
比较三种疏水丙烯酸酯人工晶状体模型对白内障超声乳化手术后一年内PCO发展的影响。
该研究纳入了72例患者(91只眼),在植入三种后房型疏水丙烯酸酯人工晶状体模型之一后进行了12个月的随访:MIOL-2(俄罗斯Reper-NN,24只眼,1组)、SA60AT和US60MP(美国爱尔康,分别为41只眼和26只眼,2组和3组)。拍摄后囊膜图像,然后用EPCO 2000(后囊膜混浊评估)软件进行处理。估计直径4.0 mm的人工晶状体光学部中心附近后囊膜的面积。PCO评分计算为混浊面积乘以程度(从0到4)的加权总和。
在随访的1年内,平均视力至少为1.0(20/20)。早在手术后3个月就观察到了明显的PCO进展。尽管如此,在每次随访时,所有三组的混浊密度均未超过2级;1组在手术后12个月时出现了最大PCO评分(中位数为0.0315)。同时,各组之间的PCO评分差异不显著。仅1组的1例患者在手术后12个月进行了Nd:YAG激光后囊膜切开术。仅在手术后12个月,1组和3组之间透明后囊膜的百分比差异显著(=0.024)。
在随访的12个月内,所有三种疏水丙烯酸酯人工晶状体模型都显示出相当高的视力结果,US60MP人工晶状体眼的PCO评分和透明后囊膜百分比略好。