Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Division of Developmental Pediatrics, Department of Pediatrics, McMaster University, Canada.
Turk J Pediatr. 2020;62(6):897-905. doi: 10.24953/turkjped.2020.06.001.
Down syndrome (DS), or trisomy 21, is the most common genetic syndrome associated with intellectual disability. Despite the variability in expression, there is a distinct developmental phenotype characterized by deficits in learning/memory, executive functions, and language skills accompanying the psychomotor delay. The severity of intellectual impairment has the dominant effect on functioning, other influences such as parental and societal attitudes, supports available and social opportunities also play a role in the attainment of skills.
唐氏综合征（DS），又称 21 三体综合征，是最常见的与智力障碍相关的遗传性综合征。尽管临床表现存在差异，但存在明显的发育表型，其特征是学习/记忆、执行功能和语言技能缺陷，伴有运动发育迟缓。智力障碍的严重程度对功能有主导影响，其他影响因素，如父母和社会态度、可用支持和社会机会，也在技能获得中发挥作用。
