Department of Obstetrics and Gynaecology, Peking University Third Hospital, Beijing, China.
Department of Laboratory Medicine, Peking University Third Hospital, Beijing, China.
Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620983898. doi: 10.1177/1076029620983898.
To investigate changes in coagulation during twin pregnancies. Methods: A total of 108 women with twin pregnancies and 442 women with singleton pregnancies were recruited. Coagulation tests, including fibrinogen (Fib), activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), were performed during the course of the pregnancy. The level of fibrinogen gradually increased during singleton pregnancies, while the APTT and PT levels showed a decreasing trend with increasing gestational weeks. In twin pregnancies, the changes in PT and TT were similar, but other parameters displayed a different trend. Fibrinogen showed no significant difference between the second and third trimesters, while APTT showed an increasing trend from the second trimester to the third trimester. Compared with singleton pregnancies, the level of fibrinogen was higher in women pregnant with twins. APTT was longer in women pregnant with twins than in women with singleton pregnancies in the third trimester. PT was shorter in women pregnant with twins than in women with singleton pregnancies in the first and third trimesters. TT was shorter in women pregnant with twins than in women with singleton pregnancies in the first and second trimesters. Through this retrospective longitudinal analysis, this study presents the main coagulation parameter changes in singleton and twin pregnancies and confirms that coagulation is more enhanced in twin pregnancies than in singleton pregnancies.
探讨双胎妊娠过程中凝血功能的变化。方法：共纳入 108 例双胎妊娠妇女和 442 例单胎妊娠妇女。在妊娠过程中进行凝血检查，包括纤维蛋白原（Fib）、活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）和凝血酶时间（TT）。单胎妊娠妇女的纤维蛋白原水平逐渐升高，而 APTT 和 PT 水平随孕周增加呈下降趋势。在双胎妊娠中，PT 和 TT 的变化相似，但其他参数呈现不同的趋势。纤维蛋白原在第二和第三孕期之间无显著差异，而 APTT 从第二孕期到第三孕期呈上升趋势。与单胎妊娠相比，双胎妊娠妇女的纤维蛋白原水平更高。双胎妊娠妇女的 APTT 在第三孕期比单胎妊娠妇女更长。双胎妊娠妇女的 PT 在第一和第三孕期比单胎妊娠妇女更短。双胎妊娠妇女的 TT 在第一和第二孕期比单胎妊娠妇女更短。通过这项回顾性纵向分析，本研究展示了单胎和双胎妊娠的主要凝血参数变化，并证实双胎妊娠的凝血功能比单胎妊娠更强。
