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1
Biosynthesis of the Immunosuppressant (-)-FR901483.
J Am Chem Soc. 2021 Jan 13;143(1):132-136. doi: 10.1021/jacs.0c12352. Epub 2020 Dec 29.
2
Stereocontrolled total synthesis of potent immunosuppressant FR901483.
Org Lett. 2004 Aug 5;6(16):2729-31. doi: 10.1021/ol049074w.
3
Enantioselective total syntheses of (-)-FR901483 and (+)-8-epi-FR901483.
J Org Chem. 2013 Jan 18;78(2):455-65. doi: 10.1021/jo302362b. Epub 2012 Dec 18.
4
Biosynthesis of a Tricyclo[6.2.2.0 ]dodecane System by a Berberine Bridge Enzyme-Like Aldolase.
Chemistry. 2019 Nov 27;25(66):15062-15066. doi: 10.1002/chem.201904360. Epub 2019 Oct 28.
5
Discovery and reconstitution of the cycloclavine biosynthetic pathway--enzymatic formation of a cyclopropyl group.
Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5117-21. doi: 10.1002/anie.201410002. Epub 2015 Feb 25.
6
A formal enantioselective total synthesis of FR901483.
Org Lett. 2012 Sep 21;14(18):4834-7. doi: 10.1021/ol302165d. Epub 2012 Aug 31.
8
Total synthesis of the immunosuppressant FR901483 via an amidoacrolein cycloaddition.
Org Lett. 2001 Apr 19;3(8):1125-8. doi: 10.1021/ol015506g.
9
Biosynthesis of Biscognienyne B Involving a Cytochrome P450-Dependent Alkynylation.
Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13531-13536. doi: 10.1002/anie.202004364. Epub 2020 May 25.
10
Total synthesis of (-)-FR901483.
Org Lett. 2012 Jul 20;14(14):3604-7. doi: 10.1021/ol301331t. Epub 2012 Jun 26.

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Genome Mining of Fungal Aza-Polycyclic Natural Products Derived from Arginine-Containing Cyclodipeptides.
J Nat Prod. 2025 Jun 27;88(6):1506-1513. doi: 10.1021/acs.jnatprod.5c00455. Epub 2025 Jun 9.
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Design and Biosynthesis of Ornithine 8-Containing Semaglutide Variants with a Click Chemistry-Modifiable Position 26.
ACS Synth Biol. 2025 May 16;14(5):1790-1801. doi: 10.1021/acssynbio.5c00132. Epub 2025 Apr 30.
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Design and Production of Geranylated Cyclic Peptides by the RiPP Enzymes SyncM and PirF.
Biomacromolecules. 2025 May 12;26(5):3186-3199. doi: 10.1021/acs.biomac.5c00260. Epub 2025 Apr 6.
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Synthetic Biology in Natural Product Biosynthesis.
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Mechanistic Perspective on C-N and C-S Bond Construction Catalyzed by Cytochrome P450 Enzymes.
ACS Bio Med Chem Au. 2024 Nov 27;5(1):16-30. doi: 10.1021/acsbiomedchemau.4c00100. eCollection 2025 Feb 19.
6
Fragment-Guided Genome Mining of Octacyclic Cyclophane Alkaloids from Fungi.
J Am Chem Soc. 2024 Aug 28;146(34):23933-23942. doi: 10.1021/jacs.4c06734. Epub 2024 Aug 14.
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Uncommon Arrangement of Self-resistance Allows Biosynthesis of de novo Purine Biosynthesis Inhibitor that Acts as an Immunosuppressor.
J Am Chem Soc. 2023 Dec 13;145(49):26883-26889. doi: 10.1021/jacs.3c09600. Epub 2023 Dec 5.
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Total Heterologous Biosynthesis of Fungal Natural Products in .
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本文引用的文献

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Recent developments in self-resistance gene directed natural product discovery.
Nat Prod Rep. 2020 Jul 1;37(7):879-892. doi: 10.1039/c9np00050j. Epub 2020 Jan 8.
2
Rapid Syntheses of (-)-FR901483 and (+)-TAN1251C Enabled by Complexity-Generating Photocatalytic Olefin Hydroaminoalkylation.
Angew Chem Int Ed Engl. 2020 Feb 3;59(6):2256-2261. doi: 10.1002/anie.201912010. Epub 2019 Dec 30.
3
Enzyme-Catalyzed Inverse-Electron Demand Diels-Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H.
J Am Chem Soc. 2019 Apr 10;141(14):5659-5663. doi: 10.1021/jacs.9b02204. Epub 2019 Mar 26.
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Enzymatic Synthesis of Psilocybin.
Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12352-12355. doi: 10.1002/anie.201705489. Epub 2017 Aug 25.
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Mechanism of the P450-Catalyzed Oxidative Cyclization in the Biosynthesis of Griseofulvin.
ACS Catal. 2016 Jul 1;6(7):4506-4511. doi: 10.1021/acscatal.6b01068. Epub 2016 May 31.
6
Biosynthesis of Strained Piperazine Alkaloids: Uncovering the Concise Pathway of Herquline A.
J Am Chem Soc. 2016 Oct 19;138(41):13529-13532. doi: 10.1021/jacs.6b09464. Epub 2016 Oct 6.
7
Extreme electric fields power catalysis in the active site of ketosteroid isomerase.
Science. 2014 Dec 19;346(6216):1510-4. doi: 10.1126/science.1259802.
9
Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis.
J Am Chem Soc. 2013 Jul 31;135(30):10962-5. doi: 10.1021/ja405518u. Epub 2013 Jul 22.
10
Enantioselective total syntheses of (-)-FR901483 and (+)-8-epi-FR901483.
J Org Chem. 2013 Jan 18;78(2):455-65. doi: 10.1021/jo302362b. Epub 2012 Dec 18.

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