State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
Org Lett. 2012 Jul 20;14(14):3604-7. doi: 10.1021/ol301331t. Epub 2012 Jun 26.
A total synthesis of the immunosuppressive alkaloid (-)-FR901483 (1) has been described. The intriguingly azatricyclic structure of 1 was constructed by the semipinacol-type rearrangement and intramolecular Schmidt reaction of an azido cyclohexanone derivative. This strategy provides a distinctive and competitive approach to the natural product 1.
已描述了免疫抑制生物碱（-）-FR901483（1）的全合成。1 的令人好奇的氮杂三环结构是通过叠氮环己酮衍生物的半频哪醇型重排和分子内施密特反应构建的。该策略为天然产物 1 提供了一种独特且有竞争力的方法。
