可见光促进的烯醇醋酸酯自由基二氟甲基化反应合成α-二氟甲基取代酮
Visible-Light-Promoted Synthesis of α-CFH-Substituted Ketones by Radical Difluoromethylation of Enol Acetates.
作者信息
Feng Zengqiang, Zhu Baoxiang, Dong Bingbing, Cheng Li, Li Yunpu, Wang Zechao, Wu Junliang
机构信息
College of Chemistry and Institute of Green Catalysis, Zhengzhou University, Zhengzhou 450001, P.R. China.
Division of Molecular Catalysis & Synthesis, Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450001, P.R. China.
出版信息
Org Lett. 2021 Jan 15;23(2):508-513. doi: 10.1021/acs.orglett.0c04021. Epub 2020 Dec 29.
An efficient and novel visible-light-promoted radical difluoromethylation of enol acetates for the synthesis of α-CFH-substituted ketones has been described. Upon irradiation under blue LED with catalytic amounts of -Ir(ppy), this photocatalytic procedure employs difluoromethyltriphenylphosphonium bromide as a radical precursor. Various α-CFH-substituted ketones are successfully created via designed systems based on the SET process. The methodology has also provided an operationally simple process with broad functional group compatibility.
本文描述了一种高效、新颖的可见光促进的烯醇醋酸酯自由基二氟甲基化反应，用于合成α-二氟甲基取代的酮。在蓝色发光二极管照射下，使用催化量的-Ir(ppy)，该光催化过程采用二氟甲基三苯基溴化鏻作为自由基前体。通过基于单电子转移（SET）过程设计的体系，成功制备了各种α-二氟甲基取代的酮。该方法还提供了一种操作简单、官能团兼容性广泛的过程。
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