School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
PLoS One. 2020 Dec 29;15(12):e0243416. doi: 10.1371/journal.pone.0243416. eCollection 2020.
To compare the value of pre-treatment axial elongation (AE) and changes in refractive sphere (M change) for predicting the success in orthokeratology (ortho-k), in order to better identify suitable candidates for myopia control.
This study further analysed the data of 66 subjects receiving 7-month ortho-k treatment, following a 7-month observation period, during which single-vision spectacles were worn. Rate of myopia progression was determined by AE and M change and subjects categorised as slow, moderate, or rapid progressors based on these changes. Outcomes of myopia control, based on the AE reduction after ortho-k, were classified as 'ineffectual', 'clinically insignificant', or 'beneficial'.
Of the 20 subjects, initially categorised as slow by AE and, of whom 95% were similarly categorised by M change, none benefitted from ortho-k. In contrast, of the 22 subjects with moderate AE, 77% and 23% displaying slow and moderate M change, respectively, the majority (73%) benefitted from ortho-k lens wear. The 24 subjects with rapid AE were poorly identified by M change, with only 21% correctly categorised. The vast majority of rapid progressors showed significant benefit after ortho-k.
Progression of AE is a good indicator of subsequent success of ortho-k treatment. Delaying commencement of therapy is prudent for children with slow progression as results indicate that they would be unlikely to benefit from this intervention. As change in refractive error frequently underestimates rapid progression of AE, its value for identifying appropriate candidates for myopia control is poor.
比较治疗前轴向伸长(AE)和屈光度变化(M 变化)在预测角膜塑形术(ortho-k)成功中的价值,以便更好地识别适合近视控制的候选者。
本研究进一步分析了 66 名接受 7 个月 ortho-k 治疗的患者的数据,在 7 个月的观察期内,患者佩戴单焦眼镜。近视进展率通过 AE 和 M 变化来确定,并根据这些变化将患者分为进展缓慢、中度或快速进展者。根据 ortho-k 后 AE 的减少,将近视控制的结果分为“无效”、“临床意义不大”或“有益”。
在 20 名最初通过 AE 归类为进展缓慢的患者中,其中 95%通过 M 变化也归类为进展缓慢,他们都没有从 ortho-k 中受益。相比之下,在 22 名 AE 中度的患者中,分别有 77%和 23%的患者 M 变化缓慢和中度,大多数(73%)从 ortho-k 镜片佩戴中受益。24 名 AE 快速进展的患者不能通过 M 变化很好地识别,只有 21%被正确归类。大多数快速进展者在 ortho-k 后表现出明显的益处。
AE 的进展是 ortho-k 治疗后续成功的良好指标。对于进展缓慢的儿童,延迟开始治疗是谨慎的,因为结果表明他们不太可能从这种干预中受益。由于屈光误差的变化经常低估 AE 的快速进展,因此其识别适合近视控制的合适候选者的价值较差。