Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; Division of Endocrinology and Metabolism, Department of Internal Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; Department of Rehabilitation Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Exp Gerontol. 2021 Mar;145:111220. doi: 10.1016/j.exger.2020.111220. Epub 2020 Dec 26.
Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskeletal comorbidities, the etiology of sarcopenia, and especially the contribution of cardiovascular aging is unclear. Aging-related vascular calcification is prevalent in older adults and is a known risk factor for cardiovascular disease and death. The effect vascular calcification has on function during aging is not well understood. Emerging findings suggest vascular calcification can impact skeletal muscle perfusion, negatively affecting nutrient and oxygen delivery to skeletal muscle, ultimately accelerating muscle loss and functional decline. The present review summarizes existing evidence on the biological mechanisms linking vascular calcification with sarcopenia during aging.
随着年龄的增长，心血管和肌肉骨骼等生物结构发生变化，导致多种合并症的发生，包括心血管疾病和虚弱，并最终导致过早死亡。然而，虚弱的老年人通常同时表现出心血管和肌肉骨骼合并症，但导致肌肉减少症的病因，尤其是心血管衰老的作用尚不清楚。与年龄相关的血管钙化在老年人中很常见，是心血管疾病和死亡的已知危险因素。血管钙化在衰老过程中对功能的影响尚不清楚。新出现的研究结果表明，血管钙化会影响骨骼肌灌注，从而对骨骼肌的营养和氧气输送产生负面影响，最终加速肌肉损失和功能下降。本综述总结了现有证据，探讨了衰老过程中血管钙化与肌肉减少症之间的生物学机制。
