Fantin Francesco, Nicolussi Paolaz Serena, Giani Anna, Mattachini Elisa, Zoico Elena, Zamboni Mauro
Centre for Medical Sciences - CISMed, Department of Psychology and Cognitive Science - DIPSCO, Section of Geriatric Medicine, University of Trento, Rovereto, Italy.
Division of Geriatric Meidcine, APSS, Rovereto, TN, Italy.
Aging Clin Exp Res. 2025 Jul 19;37(1):223. doi: 10.1007/s40520-025-03122-4.
Both sarcopenia and arterial wall stiffening are frequent findings among hospitalized older adults, and further insight should be gained to explore their pathophysiological mechanisms and possible correlations.
90 hospitalized geriatric patients (mean age 83.94 ± 6.6 years, 38.89% female, 36.7% sarcopenic) have been enrolled, and underwent clinical, comorbidity and biochemical assessment. Sarcopenia was investigated following the diagnostic algorithm according to European guidelines assessing muscular strength, using a portable dynamometer, and muscle mass by bio-impedance analysis (BIA); carotid-femoral pulse wave velocity (cfPWV), carotid-radial PWV (crPWV), femoral-pedal PWV (fpPWV) and cardio-ankle vascular index (CAVI) were obtained for each.
Sarcopenic patients (n = 33) were older (p < 0.01) than subjects without sarcopenia (n = 57). Sarcopenic patients presented higher CAVI (12.67 ± 3.12 vs. 10.91 ± 1.4, p < 0.01) and fpPWV, but not cfPWV and crPWV. In backward analysis muscle strength and comorbidity index resulted good indipendent variables of fpPWV (R 0.11), muscle strength, comorbidity index and sex could predict CAVI (R 0.22). When examining sarcopenia diagnoses determinants, in a logistic binary regression model and considering several possible covariates, fpPWV resulted a significant indipendent variable of sarcopenia along with age and sex.
increased indexes of arterial stiffness are shown in sarcopenic hospitalized older adults as compared to hospitalized patients without sarcopenia; peripheral arterial segments of the lower limb appeared to be more involved in the stiffening process, as compared to central segments.
肌肉减少症和动脉壁硬化在住院老年人中均很常见，应进一步深入了解以探索其病理生理机制及可能的相关性。
纳入90例住院老年患者（平均年龄83.94±6.6岁，女性占38.89%，肌肉减少症患者占36.7%），并进行临床、合并症及生化评估。根据欧洲指南的诊断算法，使用便携式测力计评估肌肉力量，通过生物电阻抗分析（BIA）测量肌肉质量，以调查肌肉减少症；分别获取每位患者的颈股脉搏波速度（cfPWV）、颈桡脉搏波速度（crPWV）、股踝脉搏波速度（fpPWV）和心踝血管指数（CAVI）。
肌肉减少症患者（n = 33）比无肌肉减少症的患者（n = 57）年龄更大（p < 0.01）。肌肉减少症患者的CAVI更高（12.67±3.12 vs. 10.91±1.4，p < 0.01），fpPWV也更高，但cfPWV和crPWV无差异。在向后分析中，肌肉力量和合并症指数是fpPWV的良好独立变量（R 0.11），肌肉力量、合并症指数和性别可预测CAVI（R 0.22）。在逻辑二元回归模型中检查肌肉减少症诊断的决定因素并考虑多个可能的协变量时，fpPWV与年龄和性别一起是肌肉减少症的显著独立变量。
与无肌肉减少症的住院患者相比，肌肉减少症的住院老年人动脉僵硬度指标升高；与中心动脉段相比，下肢外周动脉段似乎在硬化过程中受累更严重。
