Fang I-Mo, Hsu Hsin-Yi, Chiang Wan-Ling, Shih Yi-Ling, Han Chia-Ling
Department of Ophthalmology, Taipei City Hospital, Zhongxiao Branch, No. 87, Tonde Road, Nankang District, Taipei 10002, Taiwan.
Department of Ophthalmology, National Taiwan University Hospital, Taipei 11556, Taiwan.
J Clin Med. 2020 Dec 24;10(1):26. doi: 10.3390/jcm10010026.
The tangential traction by idiopathic epiretinal membrane (iERM) may alter the hemodynamics of the macula. We investigated the correlation between visual acuity and the optical coherence tomography angiography (OCTA) parameters in unilateral iERM.
We included 61 eyes of 61 consecutive patients with unilateral iERM between January 2018 and December 2018. The flow area of the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and choroidal capillary plexus (CCP) were measured using OCTA. The normal fellow eyes were used for comparison. The iERM patients were divided into those with a presence of foveal concavity and those with a loss of foveal concavity.
When compared with fellow eyes, the flow areas showed a statistically significant decrease in the SCP and CCP of those with iERM ( = 0.037 and = 0.011, respectively). In the DCP, no significant reduction in flow area was found in iERM ( = 0.054). The flow area of the CCP was the only factor significantly associated with best vision ( = 0.012). No significant differences in the flow areas of the SCP, DCP, and CCP were found between the presence and loss of foveal concavity.
The flow area of the CCP is an important determinant of vision, emphasizing the crucial role of choroidal circulation in iERM. Moreover, mechanical stretch by iERM is not the only mechanism affecting the flow area.
特发性视网膜前膜（iERM）产生的切线牵引力可能会改变黄斑区的血流动力学。我们研究了单侧iERM患者视力与光学相干断层扫描血管造影（OCTA）参数之间的相关性。
纳入2018年1月至2018年12月期间连续61例单侧iERM患者的61只眼。使用OCTA测量视网膜浅表毛细血管丛（SCP）、深部毛细血管丛（DCP）和脉络膜毛细血管丛（CCP）的血流面积。以对侧正常眼作为对照。将iERM患者分为存在黄斑中心凹和不存在黄斑中心凹两组。
与对侧眼相比，iERM患者的SCP和CCP血流面积有统计学显著下降（分别为P = 0.037和P = 0.011）。在DCP中，iERM患者的血流面积未发现显著减少（P = 0.054）。CCP的血流面积是与最佳视力显著相关的唯一因素（P = 0.012）。存在和不存在黄斑中心凹的患者在SCP、DCP和CCP的血流面积上未发现显著差异。
CCP的血流面积是视力的重要决定因素，强调了脉络膜循环在iERM中的关键作用。此外，iERM产生的机械性牵拉不是影响血流面积的唯一机制。
