Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico.
Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico.
Nutrients. 2020 Dec 22;13(1):4. doi: 10.3390/nu13010004.
Polyunsaturated fatty acids (PUFAs) are essential to child growth and development.
To assess the effect of PUFAs-fortified infant formula on lipid profile, growth and micronutrient status in children 12 to 30 months old.
This study is a double-blind randomized controlled clinical trial. Two study groups were assessed: (a) milk-based infant formula with micronutrients and PUFAs (PUFAs) and (b) milk-based infant formula with micronutrients, no PUFAs added (Non-PUFAs). Children received prepared formula (240 mL) twice a day, according to the color-code assigned to each infant. Anthropometric measurements and venous blood samples were taken at each day-care center at baseline, and again after four months. Total serum lipid extraction was 0.5 mL. Samples were treated and modified by the Folch method and analyzed with gas chromatography.
Changes in serum lipid profile (expressed as % FA) between baseline and four months showed a statistically significant increase in docosahexaenoic acid (DHA) (0.22 vs. -0.07, < 0.05) and Alpha-Linoleic acid (0.08 vs. 0.02, < 0.05) in infants who consumed PUFAs-fortified formula compared to Non-PUFAs-fortified formula. Infants increased their length/height-for-age Z-score: median change for the PUFAs group was 0.16 (95% CI = 0.08, 0.28) and 0.23 (95% CI = 0.14, 0.33) for Non-PUFAs, with no differences between groups. Median folate level was significantly higher among the PUFAs group compared to Non-PUFAs: -0.87 (95% CI = -1.38, -0.44) and -3.83 (95% CI = -4.65, -3.03) respectively. Consumption of both supplements was adequate and stable during the intervention.
A significant improvement was observed in the lipid profile of children who received the PUFAs-fortified milk-based formula.
多不饱和脂肪酸（PUFAs）对儿童的生长发育至关重要。
评估富含多不饱和脂肪酸（PUFAs）的婴儿配方奶粉对 12 至 30 个月大的儿童的血脂谱、生长和微量营养素状况的影响。
这是一项双盲随机对照临床试验。评估了两个研究组：（a）含微量营养素和 PUFAs 的牛奶基婴儿配方奶粉和（b）含微量营养素、未添加 PUFAs 的牛奶基婴儿配方奶粉（非 PUFAs）。根据每个婴儿的颜色编码，儿童每天接受两次准备好的配方奶（240 毫升）。在基线时和四个月后，在每个日托中心进行人体测量和静脉血样采集。总血清脂质提取量为 0.5 毫升。采用 Folch 法处理和改良样品，并采用气相色谱法进行分析。
血清脂质谱（以 FA%表示）在基线和四个月之间的变化表明，与非 PUFAs 强化配方组相比，食用富含 PUFAs 的配方奶粉的婴儿的二十二碳六烯酸（DHA）（0.22 对-0.07，<0.05）和α-亚麻酸（0.08 对 0.02，<0.05）显著增加。婴儿的身高/年龄 Z 分数增加：PUFAs 组的中位数变化为 0.16（95%CI=0.08，0.28）和 0.23（95%CI=0.14，0.33），而非 PUFAs 组无差异。与非 PUFAs 组相比，PUFAs 组的叶酸水平中位数显著升高：-0.87（95%CI=-1.38，-0.44）和-3.83（95%CI=-4.65，-3.03）。两种补充剂在干预期间的摄入量均充足且稳定。
接受富含 PUFAs 的牛奶基配方奶粉的儿童血脂谱显著改善。
