Gonzalez-Casanova Ines, Stein Aryeh D, Hao Wei, Garcia-Feregrino Raquel, Barraza-Villarreal Albino, Romieu Isabelle, Rivera Juan A, Martorell Reynaldo, Ramakrishnan Usha
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA;
Health and Nutrition Research Center and.
J Nutr. 2015 Jun;145(6):1330-4. doi: 10.3945/jn.114.203570. Epub 2015 Apr 29.
Prenatal supplementation with docosahexaenoic acid (DHA) has been shown to increase birth size, but it is unclear whether these differences translate into improved postnatal growth.
We assessed the effect of prenatal supplementation with DHA on offspring weight, length, and body mass index (BMI) through 60 mo of age.
We examined growth patterns (height, weight, and BMI) in a cohort of 802 Mexican children whose mothers participated in a randomized, controlled trial of daily supplementation with 400 mg/d of DHA or a placebo from week 18-22 of gestation through delivery, with the use of a longitudinal multilevel model of growth.
Overall, means ± SDs of height-, weight-, and BMI-for-age z scores relative to WHO growth standards at 60 mo were -0.49 ± 0.91, -1.15 ± 1.07 and 0.13 ± 1.11, respectively. There were no significant differences by treatment group (all P > 0.05) for height, weight, or BMI at any age through 60 mo. Similarly, DHA did not affect the average growth or the trajectories for these measures through 60 mo.
Prenatal DHA supplementation did not affect height, weight, or BMI through 60 mo of age. This trial was registered at clinicaltrials.gov as NCT00646360.
已表明产前补充二十二碳六烯酸（DHA）可增加出生时的体重，但尚不清楚这些差异是否会转化为出生后更好的生长发育。
我们评估了产前补充DHA对后代60月龄时体重、身长和体重指数（BMI）的影响。
我们研究了802名墨西哥儿童的生长模式（身高、体重和BMI），这些儿童的母亲参与了一项随机对照试验，从妊娠第18 - 22周直至分娩，每日补充400mg/d的DHA或安慰剂，采用纵向多水平生长模型进行分析。
总体而言，相对于世界卫生组织生长标准，60月龄时年龄别身高、体重和BMI的z评分均值±标准差分别为 - 0.49±0.91、 - 1.15±1.07和0.13±1.11。在60月龄前的任何年龄，治疗组之间在身高、体重或BMI方面均无显著差异（所有P>0.05）。同样，DHA在60月龄前未影响这些指标的平均生长或生长轨迹。
产前补充DHA在60月龄时未影响身高、体重或BMI。该试验在clinicaltrials.gov上注册，注册号为NCT00646360。
