尿F2-异前列腺素浓度在动脉瘤性蛛网膜下腔出血后迟发性脑缺血中的作用——一个不良预后因素
The Role of Urine F2-ISOPROSTANE CONcentration in Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Haemorrhage-A Poor Prognostic Factor.
作者信息
Wiśniewski Karol, Popęda Marta, Tomasik Bartłomiej, Bieńkowski Michał, Bobeff Ernest J, Stefańczyk Ludomir, Tybor Krzysztof, Hupało Marlena, Jaskólski Dariusz J
机构信息
Department of Neurosurgery and Neurooncology, Barlicki University Hospital, Medical University of Lodz, Kopcińskiego 22, 90-153 Lodz, Poland.
Laboratory of Translational Oncology, Intercollegiate Faculty of Biotechnology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk, Poland.
出版信息
Diagnostics (Basel). 2020 Dec 22;11(1):5. doi: 10.3390/diagnostics11010005.
The pathophysiology of delayed cerebral ischemia (DCI) remains unclear. One of the hypotheses suggests that reactive oxygen species play a role in its onset. Thus, we studied F2-isoprostanes (F2-IsoPs)-oxidative stress biomarkers. Our goal was to improve the early diagnosis of DCI in a non-invasive way. We conducted a prospective single center analysis of 38 aneurysmal subarachnoid hemorrhage patients. We assessed urine F2-IsoP concentration using immunoenzymatic arrays between the first and fifth day after bleeding. A correlation between urine F2-IsoP concentration and DCI occurrence was examined regarding clinical conditions and outcomes. The urine F2-IsoP concentrations were greater than those in the control groups ( < 0.001). The 3rd day urine F2-IsoPs concentrations were correlated with DCI occurrence ( < 0.001) and long term outcomes after 12 months ( < 0.001). High levels of urine F2-IsoPs on day 3 can herald DCI.
迟发性脑缺血（DCI）的病理生理学仍不清楚。其中一种假说是活性氧在其发病过程中起作用。因此，我们研究了F2-异前列腺素（F2-IsoPs）——氧化应激生物标志物。我们的目标是以非侵入性方式改善DCI的早期诊断。我们对38例动脉瘤性蛛网膜下腔出血患者进行了前瞻性单中心分析。我们在出血后的第一天至第五天使用免疫酶阵列评估尿F2-IsoP浓度。就临床情况和结果而言，研究了尿F2-IsoP浓度与DCI发生之间的相关性。尿F2-IsoP浓度高于对照组（<0.001）。第3天的尿F2-IsoPs浓度与DCI的发生（<0.001）和12个月后的长期结果（<0.001）相关。第3天尿F2-IsoPs水平升高可预示DCI。
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