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藻类和特级初榨橄榄油混合物对老龄啮齿动物骨骼肌的年龄相关改变的有益作用：组蛋白去乙酰化酶-4 的作用。

Beneficial Effects of a Mixture of Algae and Extra Virgin Olive Oils on the Age-Induced Alterations of Rodent Skeletal Muscle: Role of HDAC-4.

机构信息

Department of Physiology, Faculty of Medicine, Autonomous University of Madrid, 28049 Madrid, Spain.

Pharmactive Biotech Products S.L. Parque Científico de Madrid, Avenida del Doctor Severo Ochoa, 37 Local 4J, 28108 Alcobendas, Spain.

出版信息

Nutrients. 2020 Dec 25;13(1):44. doi: 10.3390/nu13010044.

DOI:10.3390/nu13010044
PMID:33375628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7824654/
Abstract

Aging is associated with a progressive decline in skeletal muscle mass, strength and function (sarcopenia). We have investigated whether a mixture of algae oil (25%) and extra virgin olive oil (75%) could exert beneficial effects on sarcopenia. Young (3 months) and old (24 months) male Wistar rats were treated with vehicle or with the oil mixture (OM) (2.5 mL/kg) for 21 days. Aging decreased gastrocnemius weight, total protein, and myosin heavy chain mRNA. Treatment with the OM prevented these effects. Concomitantly, OM administration decreased the inflammatory state in muscle; it prevented the increase of pro-inflammatory interleukin-6 (IL-6) and the decrease in anti-inflammatory interleukin-10 (IL-10) in aged rats. The OM was not able to prevent aging-induced alterations in either the insulin-like growth factor I/protein kinase B (IGF-I/Akt) pathway or in the increased expression of atrogenes in the gastrocnemius. However, the OM prevented decreased autophagy activity (ratio protein 1A/1B-light chain 3 (LC3b) II/I) induced by aging and increased expression of factors related with muscle senescence such as histone deacetylase 4 (HDAC-4), myogenin, and IGF-I binding protein 5 (IGFBP-5). These data suggest that the beneficial effects of the OM on muscle can be secondary to its anti-inflammatory effect and to the normalization of HDAC-4 and myogenin levels, making this treatment an alternative therapeutic tool for sarcopenia.

摘要

衰老是与骨骼肌质量、力量和功能（肌少症）的逐渐下降相关的。我们研究了藻油（25%）和特级初榨橄榄油（75%）的混合物是否对肌少症有有益的影响。年轻（3 个月）和年老（24 个月）雄性 Wistar 大鼠用载体或油混合物（OM）（2.5 mL/kg）处理 21 天。衰老降低了比目鱼肌的重量、总蛋白和肌球蛋白重链 mRNA。用 OM 处理可预防这些影响。同时，OM 给药可降低肌肉中的炎症状态；它可预防衰老大鼠中促炎细胞因子白细胞介素-6（IL-6）的增加和抗炎细胞因子白细胞介素-10（IL-10）的减少。OM 不能预防衰老引起的胰岛素样生长因子 I/蛋白激酶 B（IGF-I/Akt）通路或比目鱼肌中自噬基因表达的增加的改变。然而，OM 可预防衰老引起的自噬活性（1A/1B-轻链 3（LC3b）II/I 蛋白比）降低，并增加与肌肉衰老相关的因子的表达，如组蛋白去乙酰化酶 4（HDAC-4）、成肌细胞生成素和 IGF-I 结合蛋白 5（IGFBP-5）。这些数据表明，OM 对肌肉的有益影响可能与其抗炎作用和 HDAC-4 和成肌细胞生成素水平的正常化有关，使其成为肌少症的一种替代治疗工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/1d982adb59a1/nutrients-13-00044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/84f2ea0d8621/nutrients-13-00044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/3807d890cdd7/nutrients-13-00044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/58c2a4728e11/nutrients-13-00044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/a2fcfa5ea132/nutrients-13-00044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/25ce891bfa38/nutrients-13-00044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/1d982adb59a1/nutrients-13-00044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/84f2ea0d8621/nutrients-13-00044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/3807d890cdd7/nutrients-13-00044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/58c2a4728e11/nutrients-13-00044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/a2fcfa5ea132/nutrients-13-00044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/25ce891bfa38/nutrients-13-00044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/935c/7824654/1d982adb59a1/nutrients-13-00044-g006.jpg

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