Roy A, Guthrie S, Karoum F, Pickar D, Linnoila M
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
Arch Gen Psychiatry. 1988 Feb;45(2):158-61. doi: 10.1001/archpsyc.1988.01800260072009.
We examined the intercorrelations among urinary outputs of norepinephrine (NE) and its three major metabolites in unipolar depressed patients (n = 28) and normal controls (n = 24). Among the depressed patients, levels of NE correlated with normetanephrine (NM), 3-methoxy-4-hydroxyphenylglycol (MHPG), and vanillylmandelic acid (VMA), and VMA correlated with NM and MHPG. In the total group of depressed and control subjects (n = 52), the sum of NE and its major metabolites correlated with urinary outputs of NE, NM, MHPG, and VMA. These highly significant correlations among urinary outputs of NE and its major metabolites replicate a previous report of strong correlations among these same four urinary substances in a smaller group of depressed patients.
我们研究了单相抑郁症患者（n = 28）和正常对照组（n = 24）中去甲肾上腺素（NE）及其三种主要代谢产物的尿排出量之间的相互关系。在抑郁症患者中，NE水平与去甲变肾上腺素（NM）、3-甲氧基-4-羟基苯乙二醇（MHPG）和香草扁桃酸（VMA）相关，且VMA与NM和MHPG相关。在抑郁症患者和对照组的总样本（n = 52）中，NE及其主要代谢产物的总和与NE、NM、MHPG和VMA的尿排出量相关。NE及其主要代谢产物尿排出量之间的这些高度显著的相关性重复了之前在一小群抑郁症患者中关于这四种尿液物质之间强相关性的报告。
