Gulias-Cañizo Rosario, Benatti Andres, De Wit-Carter Guillermo, Hernández-Quintela Everardo, Sánchez-Huerta Valeria
Universidad Anahuac Mexico, Huixquilucan, Estado de Mexico, Mexico.
Cordoba Eye Clinic, Cornea and Refractive Surgery Department, Cordoba, Argentina.
Clin Ophthalmol. 2020 Dec 21;14:4451-4457. doi: 10.2147/OPTH.S284306. eCollection 2020.
To investigate the efficacy of photoactivated chromophore corneal collagen cross-linking (PACK)-CXL in the management of treatment-resistant infectious keratitis.
Observational cohort study.
Forty-two eyes from 41 patients with treatment-resistant infectious keratitis.
Eyes underwent PACK-CXL treatment with the Dresden modified protocol in addition to standard antimicrobial therapy. The primary endpoint was the size of the corneal ulcer. Descriptive statistics, Wilcoxon rank test, McNemar test and Spearman correlation coefficient were used for statistical analysis, and values lower than 0.05 were considered statistically significant.
Success rate at third postoperative month was of 90.5%. Statistical analyses showed a significant effect of (PACK)‑CXL with standard antimicrobial therapy to reduce corneal ulcer size (p=0.031).
As adjuvant therapy to standard antimicrobial treatment, PACK-CXL improves the outcomes in patients with treatment-resistant corneal ulcers.
探讨光活化发色团角膜胶原交联术（PACK）-CXL治疗难治性感染性角膜炎的疗效。
观察性队列研究。
41例难治性感染性角膜炎患者的42只眼。
除标准抗菌治疗外，采用德累斯顿改良方案对眼睛进行PACK-CXL治疗。主要终点是角膜溃疡的大小。采用描述性统计、Wilcoxon秩和检验、McNemar检验和Spearman相关系数进行统计分析，P值低于0.05被认为具有统计学意义。
术后第三个月的成功率为90.5%。统计分析表明，（PACK）-CXL联合标准抗菌治疗对减小角膜溃疡大小有显著效果（P=0.031）。
作为标准抗菌治疗的辅助疗法，PACK-CXL可改善难治性角膜溃疡患者的治疗效果。
