Lin Yan, He Ziqin, Ye Jiazhou, Liu Ziyu, She Xiaomin, Gao Xing, Liang Rong
Department of Medical Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, People's Republic of China.
Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, People's Republic of China.
Onco Targets Ther. 2020 Dec 21;13:13023-13032. doi: 10.2147/OTT.S278013. eCollection 2020.
As a pleiotropic cytokine, interleukin-6 (IL-6) not only regulates the cellular immune response, but it also promotes tumor development by activating multiple carcinogenic pathways. IL-6 expression is significantly elevated in colorectal cancer (CRC) and is closely related to CRC development and patient prognosis. In CRC, IL-6 activates signal transducers and activators of transduction-3 (STAT3) to promote tumor initiation and tumor growth. IL-6/STAT3 signalling has a profound effect on tumor-infiltrating immune cells in the tumor immune microenvironment in CRC. Additionally, IL-6/STAT3 pathway activates downstream target genes to protect tumor cells from apoptosis; drive tumor cell proliferation, cell cycle progression, invasion and metastasis; promote tumor angiogenesis; and stimulate drug resistance. Therefore, a thorough understanding of the many effects of the IL-6/STAT3 pathway in CRC is needed, which the present review examines.
作为一种多效性细胞因子，白细胞介素-6（IL-6）不仅调节细胞免疫反应，还通过激活多种致癌途径促进肿瘤发展。IL-6在结直肠癌（CRC）中的表达显著升高，且与CRC的发展及患者预后密切相关。在CRC中，IL-6激活信号转导和转录激活因子3（STAT3）以促进肿瘤起始和肿瘤生长。IL-6/STAT3信号传导对CRC肿瘤免疫微环境中的肿瘤浸润免疫细胞具有深远影响。此外，IL-6/STAT3通路激活下游靶基因，以保护肿瘤细胞免于凋亡；驱动肿瘤细胞增殖、细胞周期进程、侵袭和转移；促进肿瘤血管生成；并刺激耐药性。因此，需要深入了解IL-6/STAT3通路在CRC中的多种作用，本综述对此进行了探讨。
