Kamioka Hiroharu, Mori Yasunori, Horiuchi Takahiko, Hayashi Takahito, Ohmura Koichiro, Yamaguchi Satoru, Kato Mitsutoshi
Faculty of Regional Environment Science, Tokyo University of Agriculture, Tokyo, Japan.
Mie Prefecture Health and Environment Research Institute, Yokkaichi, Mie, Japan.
Diabetes Metab Syndr Obes. 2020 Dec 22;13:5059-5069. doi: 10.2147/DMSO.S279270. eCollection 2020.
To clarify the relationship between daily hot water bathing (HWB) at home and glycemic control in middle-aged and elderly ambulatory patients with type 2 diabetes mellitus (T2DM).
We defined hemoglobin A1c (HbA1c) as the main outcome. We set 7.0% based on the mean value of the dependent variable as the cut-off point for analysis. Frequency of HWB was an explanatory variable. A two-sample -test was used to compare between groups with continuous variables. Multiple logistic regression analysis was performed for frequency, adjusted age, sex, BMI, T2DM duration (Model 1), and other confounding factors (Model 2). Odds ratio (OR) and 95% confidence interval (95% CI) were calculated.
Among 838 patients, there was a significant difference (p<0.001) in age between males (n=528, 62.8±8.7 years) and females (n=310, 65.0±8.1 years). In Model 1, compared with participants who used HWB more than seven times a week, those with poorly controlled HbA1c were significantly associated with low frequency of HWB: four to six times a week (OR 1.32, 95% CI 0.87-1.99) and less than three times a week (OR 1.43, 95% CI 0.98-2.10); p-value for overall trend was 0.041. In Model 2, p-value for overall trend was 0.138.
A higher frequency of HWB was moderately associated with a decreased risk of poor glycemic control in middle-aged and elderly ambulatory patients with T2DM.
阐明居家日常热水沐浴(HWB)与中老年2型糖尿病(T2DM)门诊患者血糖控制之间的关系。
我们将糖化血红蛋白(HbA1c)定义为主要结局指标。以因变量的均值为基础设定7.0%作为分析的截断点。HWB频率为解释变量。采用两样本t检验对连续变量组间进行比较。对频率、调整后的年龄、性别、体重指数、T2DM病程(模型1)以及其他混杂因素(模型2)进行多因素逻辑回归分析。计算比值比(OR)和95%置信区间(95%CI)。
在838例患者中,男性(n = 528,62.8±8.7岁)和女性(n = 310,65.0±8.1岁)之间年龄存在显著差异(p<0.001)。在模型1中,与每周使用HWB超过7次的参与者相比,HbA1c控制不佳者与HWB低频显著相关:每周4至6次(OR 1.32,95%CI 0.87 - 1.99)和每周少于3次(OR 1.43,95%CI 0.98 - 2.10);总体趋势的p值为0.041。在模型2中,总体趋势的p值为0.138。
在中老年T2DM门诊患者中,较高频率的HWB与血糖控制不佳风险降低适度相关。