Lai Jing, Bai Yuan-Liang, Bai Yin, Mei Jie, Zhang Zhi-Wei, Tang Wen-Jing, Huang Jiao
Dept. of Periodontics, Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing 400015, China;Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 400015, China.
Dept. of Periodontics, Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing 400015, China;Chongqing Medical University, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 400015, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Dec 1;38(6):672-680. doi: 10.7518/hxkq.2020.06.012.
A study was conducted to systematically evaluate the clinical efficacy of inflammatory factors in patients with chronic kidney disease and periodontitis after non-surgical periodontal therapy.
We searched the databases of CNKI, Wanfang, CBM, PubMed, Embase, and Cochrane Library from inception to December 2019. Two reviewers independently collected all literature related to inflammatory factors in patients with chronic kidney disease and periodontitis after non-surgical periodontal therapy. These factors include C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). The literature was screened according to the inclusion and exclusion criteria. The quality of the studies was strictly evaluated, and the data were extracted. The literature of randomized controlled trials in accordance with the standards was Meta-analyzed with Revman 5.3 software.
Six randomized controlled trials were included. Compared with the control groups, the results of meta-analysis showed that non-surgical periodontal therapy significantly reduced the levels of CRP [MD=-0.58, 95%CI (-1.13, -0.02), P=0.04] and IL-6 [MD=-2.76, 95%CI (-5.15, -0.37), P=0.02] in these patients but not that of TNF-α [MD=-3.87, 95%CI (-8.79, 1.05), P=0.12].
Simultaneous regular renal treatment and non-surgical periodontal therapy can help relieve the periodontal damage on patients with chronic kidney disease and periodontitis. Moreover, it can improve the status of some inflammatory factors. This finding is conducive to the control and treatment of chronic kidney disease and periodontitis and needs to be a focus of research and in clinical operation.
进行一项研究以系统评估非手术牙周治疗后慢性肾脏病合并牙周炎患者炎症因子的临床疗效。
检索中国知网、万方、中国生物医学文献数据库、PubMed、Embase和Cochrane图书馆数据库，检索时间从建库至2019年12月。两名研究者独立收集所有与非手术牙周治疗后慢性肾脏病合并牙周炎患者炎症因子相关的文献。这些因子包括C反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。根据纳入和排除标准对文献进行筛选。严格评估研究质量并提取数据。使用Revman 5.3软件对符合标准的随机对照试验文献进行Meta分析。
纳入6项随机对照试验。与对照组相比，Meta分析结果显示，非手术牙周治疗显著降低了这些患者的CRP水平[MD=-0.58，95%CI（-1.13，-0.02），P=0.04]和IL-6水平[MD=-2.76，95%CI（-5.15，-0.37），P=0.02]，但未降低TNF-α水平[MD=-3.87，95%CI（-8.79，1.05），P=0.12]。
同时进行规范的肾脏治疗和非手术牙周治疗有助于缓解慢性肾脏病合并牙周炎患者的牙周损害。此外，还可改善某些炎症因子状态。这一发现有利于慢性肾脏病和牙周炎的控制与治疗，值得临床研究和操作关注。
